道地产区不同栽培品种阳春砂水提液止泻作用研究  

Antidiarrheal Effect of Aqueous Extracts from Three Different Cultivars of Amomum Villosum Lour. Bred in Geo-Authentic Production Area

作　　者：潘怀耿[1] 李茹柳[1] 宁鑫[2] 徐晖[2] 詹若挺[2] 陈蔚文[1,2] 

机构地区：[1]广州中医药大学脾胃研究所,广州510405 [2]广州中医药大学中药资源科学与工程研究中心教育部(省部共建)中药资源科学重点实验室,广州510006

出　　处：《世界科学技术-中医药现代化》2011年第5期856-859,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家发展和改革委员会中药材扶持专项(粤经贸工业[2007]1055):阳春涛优良品种选育推广与优质中药材生产;负责人:陆锡傍;陈蔚文;科学技术部国家"十一五"科技支撑计划子课题(2006BAI09B01-06):阳春砂优质高产新品种的研究;负责人:徐晖;国家中医药管理局国家中医药行业科研专项子课题(200807020):阳春砂道地药材的形成模式;商品规格及其行业标准的研究;负责人:詹若挺

摘　　要：目的:全面了解道地产区阳春砂水提液的止泻作用,为阳春砂品种鉴定和良种选育提供实验依据。方法:采用番泻叶致小鼠腹泻模型,比较道地产区不同区域产的同一栽培品种阳春砂(长果)、道地产区不同栽培品种阳春砂(长果、圆果、春选)以及道地产区不同炮制方法制得的阳春砂的止泻药效;还进行了新选育品种春选水提液止泻的量-时-效关系实验。结果:在3 g.kg-1或4 g.kg-1剂量时,12个阳春砂水提液样品中11个有止泻作用;春选水提液量效与时效的实验结果提示其止泻的最佳剂量为4.8 g.kg-1,且在4 h时止泻效果最好。结论:道地产区阳春砂水提液有较好的止泻作用。There are two cultivars（＂Changguo＂,＂Yuanguo＂） and a newly breeding cultivar（＂Chunxuan＂） of Amomum villosum Lour.bred in geo-authentic production area Yangchun,Guangdong province.The aim of present study was to evaluate their antidiarrheal effect and provide pharmacological data needed for cultivar identification,selection and breeding.The antidiarrheal effect of aqueous extracts of A.villosum was studied by rhubarb-induced diarrhea model in mice,in respect of growing sub-areas,cultivars and preparation methods.Furthermore,the time-effect and dose-effect relationships of ＂Chunxuan＂ against diarrhea were observed.The results showed that 11 of 12 aqueous extracts of A.villosum tested were effective against diarrhea when the administration dose was 3 g/kg or 4 g/kg.The best effect was found 4 h after the mice were administered with a dose of 4.8 g/kg of ＂Chunxuan＂.It is concluded that aqueous extracts of A.villosum.bred in geo-authentic production area is with good antidiarrheal effect.

关 键 词：道地药材 道地产区 阳春砂 水提液 止泻 

分 类 号：R286.53[医药卫生—中药学]