额尔敦-乌日勒在家兔动脉粥样硬化斑块消退中的作用及其对炎症因子的影响  

Effect of Eerdun-Wurili on Rabbit Atherosclerosis Recession and Inflammation Factors

作　　者：麻春杰[1] 董平[1] 韩雪梅[1] 王滨[1] 图门巴雅尔[1] 李志茹[1] 温都苏毕力格 都格尔[1] 

机构地区：[1]内蒙古医学院,呼和浩特010110

出　　处：《世界科学技术-中医药现代化》2011年第5期894-898,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然基金委地区科学基金项目(30860386):蒙药额尔敦-乌日勒抗动脉粥样硬化的分子机制研究;负责人:麻春杰

摘　　要：目的:观察额尔敦-乌日勒对动脉粥样硬化消退的影响,并检测相关炎症因子,探讨其作用机制。方法:用高胆固醇喂养方法复制家兔动脉粥样硬化模型,并予额尔敦-乌日勒干预治疗12w。于实验结束时检测血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HLD-C)和血清中炎性标志物高敏C反应蛋白(hs-PCR)含量,以及血管细胞粘附分子-1(VCAM-1)的水平;观察各组家兔主动脉动脉粥样硬化情况;检测主动脉中VCAM-1 mRNA表达水平。结果:与自然消退组比较,额尔敦-乌日勒治疗组的血清TC、TG、LDL-C水平降低,HLD-C变化不明显;主动脉斑块面积占总面积的百分比及内膜/中膜厚度比减小;血清中hs-PCR含量和VCAM-1水平降低,主动脉VCAM-1mRNA表达水平下降。结论:额尔敦-乌日勒对早期动脉粥样硬化具有消退作用,其机制可能与降脂、抗炎有关。The study is aimed to observe the effect of Eerdun-wurili on atherosclerosis recession.Related inflammation factors were detected in the mechanism discussion.High cholesterol feeding method was used in the rabbit atherosclerosis model establishment.Eerdun-wurili was used in a 12-week treatment.Content of serum total cholesterol（TC）,triglycerides（TG）,low-density lipoprotein cholesterol（LDL-C）,high-density lipoprotein cholesterol（HLD-C）,and serum inflammatory markers hypersensitive C-reactive protein（hs-PCR） were detected after the experiment.Level of vascular cellular adhesive molecular-1（VCAM-1） was also tested.The aortic atherosclerosis severity was observed.The VCAM-1 mRNA expression level in the aorta was also observed.The results showed that compared with natural recession group,level of serum TC,TG,LDL-C in the treatment group were reduced.The content change of HLD-C was not significant.The percentage of aortic plaque area in total area and the ratio between inner-membrane and tunica media were also decreased.Serum hs-PCR content and VCAM-1 level were reduced.VCAM-1mRNA aortic expression level was also declined.It is concluded that Eerdun-wurili plays a recession role in early atherosclerosis.Its mechanism may be related to cholesterol-lowering and anti-inflammation.

关 键 词：额尔敦-乌日勒 动脉粥样硬化 病理学 高敏C 反应蛋白 血管细胞粘附分子-1 

分 类 号：R285.5[医药卫生—中药学]