A型流感病毒跨种传播和致病性相关蛋白研究进展  

Progress on Proteins Related to Cross-species Transmission and Pathogenicity of Influenza A Viruses

作　　者：于志君[1,2] 朱晓文[3] 刘红[4] 李硕[4] 范宝静[4] 王世申[4] 吴静[4] 武艳丽[4] 王铁成[3] 杨松涛[3] 黄耕[3] 高玉伟[3] 夏咸柱[3] 

机构地区：[1]吉林大学畜牧兽医学院,吉林长春130062 [2]中国人民解放军军事医学科学院军事兽医研究所,吉林省人畜共患病预防与控制重点实验室,吉林长春130122 [3]中国人民解放军军事医学科学院军事兽医研究所吉林省人畜共患病预防与控制重点实验室,吉林长春130122 [4]长春市疾病预防控制中心,吉林长春130033

出　　处：《动物医学进展》2011年第11期90-94,共5页Progress In Veterinary Medicine

基　　金：吉林省卫生厅科研基金(2009zc017)

摘　　要：A型流感病毒是重要的人和动物病原体,每年都会在人群中引发季节性流感流行,偶尔还会引发全球流感大流行,对公共卫生安全构成严重威胁。研究发现,A型流感病毒的跨种传播与该病毒的多个蛋白有关,其中血凝素是该病毒宿主范围的主要限制因素,但聚合酶蛋白和非结构蛋白1(NS1)的作用也不容忽视。A型流感病毒通过不断地适应各类宿主和长期地进化,每年都能够产生大量致病性未知且具有潜在流行性的新毒株,人们经过长期地研究发现,A型流感病毒的致病性主要受该病毒的聚合酶蛋白、血凝素蛋白和非结构蛋白1(NS1)上某些特定氨基酸的影响。论文从以上几方面对A型流感病毒跨种传播和致病性分子机制的研究进展进行综述。Influenza A viruses are important human and animal pathogens.They cause seasonal epidemics and occasional global pandemics,so they pose a serious public health threat.Multiple proteins of influenza A viruses are implicated in the cross-species transmission of these viruses,of which the virus hemagglutinin is the major limiting factor in host range,however,the polymerase protein and the non-structural protein 1 also play an important role.In each year,there are a various of new strains with unknown pathogenicity by constantly adapting to various hosts and long-term evolution,the pathogenicity of influenza A viruses are mainly affected by certain specific amino acid substitutions of polymerase protein,hemagglutinin and non-structural protein 1.In this paper,the research progress on the molecular mechanism of cross-species transmission and pathogenicity of influenza A viruses were reviewed.

关 键 词：A型流感病毒 跨种传播 致病性 分子机制 

分 类 号：S852.659[农业科学—基础兽医学]