压力性尿失禁大鼠阴道壁及肛提肌组织 TGFβ-3,Lamin,Relaxin的表达  

The Expression of TGFβ-3,Lamin,Relaxin in the Vaginal Wall and Levator Ani of Rat Model of Stress Urinary Incontinence

作　　者：张莹安[1] 李兆艾[1] 

机构地区：[1]山西省妇幼保健院妇产科,太原030001

出　　处：《国际妇产科学杂志》2011年第5期443-445,共3页Journal of International Obstetrics and Gynecology

摘　　要：目的:探讨转化生长因子β-3(TGFβ-3)、层黏连蛋白(Lamin)和松弛素(Relaxin)mRNA的表达与压力性尿失禁(SUI)鼠发病的关系。方法:分别提取SUI模型鼠与正常大鼠(各8只)的阴道前壁及肛提肌组织,提取组织中RNA,采用反转录聚合酶链反应(RT-PCR)法分别测定上述3种因子含量的变化。结果:SUI大鼠与正常大鼠比较,阴道前壁和肛提肌中TGFβ-3 mRNA和Lamin mRNA的表达明显降低,Relaxin mRNA的表达明显增高,差异有统计学意义(均P<0.05)。结论:SUI的发生与阴道前壁及肛提肌组织中TGFβ-3、Lamin表达减少、Relaxin表达增多有关。Objective：To detect the relationship between mRNA expression of three factors（TGFβ-3,Lamin, Relaxin）with stress urinary incontienece rats model. Methods：Seperately extrat the RNA in Levator ani and Vaginal of stress urinary incontienece rats model and normal rats（8 rats）. Use the RT-PCR method to detect the continence of Levator ani and Vaginal of stress urinary incontienece rats model and normal rats. Results：Compared with SUI rats and nomal rats,TGFβ-3 mRNA expression in levator ani and vagina are significant decreased（P0.05）. Lamin mRNA expression in levator ani and vagina are significant decreased（P0.05）. Relaxin mRNA expression in levator ani and vagina are significant higher（P0.05）. Conclusions：There is close relationship between occurrence of SUI and deficiency of TGFβ-3 and Lamin and increasing of Relaxin.

关 键 词：尿失禁 压力性 转化生长因子Β3 层黏连蛋白 松弛素 

分 类 号：R694.5[医药卫生—泌尿科学]