高龄妇女体外受精-胚胎移植助孕结局分析  

Analysis of the Outcome of in Vitro Fertilization and Embryo Transfer of Women with Advanced Age

作　　者：邓彬[1] 李予[1] 王文军[1] 陈向红[1] 陈玉珍[1] 阙文清[1] 杨冬梓[1] 张清学[1] 

机构地区：[1]中山大学孙逸仙纪念医院生殖中心,广州510120

出　　处：《国际妇产科学杂志》2011年第5期458-460,共3页Journal of International Obstetrics and Gynecology

摘　　要：目的:探讨高龄妇女接受体外受精-胚胎移植(IVF-ET)治疗后的助孕结局。方法:对2001年7月—2009年7月中山大学孙逸仙纪念医院生殖中心行IVF-ET治疗的高龄妇女(≥35岁)的753个取卵周期的临床资料进行回顾性分析。按妇女年龄分为4组:A组(35～36岁),B组(37～38岁),C组(39～40岁),D组(≥41岁),分析不同组的IVF-ET结局。结果:724个移植周期(另外29个周期无胚胎移植),97个周期获活产,活产率为13.4%。随年龄增长,获卵数明显减少,各组分别为(9.8±6.0),(8.6±5.4),(6.7±4.3),(5.3±4.4)个;胚胎种植率明显下降,分别为17.9%,12.8%,10.0%和4.3%;活产率明显下降,分别为16.7%,13.3%,12.4%和2.3%。各组上述指标差异均有统计学意义(P分别为0.001,0.001和0.006)。年龄≥43岁的45例患者中无一例获得活产。结论:随年龄增长,高龄妇女接受IVF-ET治疗后的胚胎种植率和活产率明显下降,40岁以后下降更为明显。IVF治疗是否应设定年龄上限有待进一步研究。Objective：To observe the influence of advanced female age on the outcome of in vitro fertilization and embryo transfer（IVF-ET）. Methods：Total of 753 IVF-ET cycles of women with age ≥35 years old from July 2001 to July 2009 were analyzed. According to female age,the patients were divided into 4 groups：group A（35-36 years）,group B（37-38 years）,group C（39-40 years）,group D（≥41 years）. Results：The live birth rate of 724 cycles with embryos transferred was 13.3%. With the increasing of age,the number of oocytes retrieved,the implantation rate and the live birth rate significantly decreased（P values were 0.001,0.001 and 0.006,respectively）. The number of oocytes retrieved were 9.8±6.0,8.6±5.4,6.7±4.3 and 5.3±4.4,respectively. The implantation rates were 17.9%,12.8%,10.0% and 4.3%,respectively. The live birth rates were 16.7%,13.3%,12.4% and 2.3%,respectively. No live birth was obtained by 45 women aged ≥43 years. Conclusions：With the age increases,the implantation rate and live birth rate of IVF-ET decrease significantly which is more obvious when the age older than 40 years. Advanced researches are needed to determine the upper limit of age for IVF.

关 键 词：受精 体外 胚胎移植 妊娠结局 年龄因素 

分 类 号：R714.8[医药卫生—妇产科学]