缺铁性贫血对大鼠甲状腺功能的影响  

Effects of Iron Deficiency Anemia on Thyroid Function in Rats

作　　者：林来祥[1] 李永梅[1] 孙毅娜[1] 叶艳[1] 张媛[2] 李丽[2] 阎玉芹[1] 陈祖培[1] 

机构地区：[1]天津医科大学代谢病医院内分泌研究所卫生部及天津市"激素与发育重点实验室",天津300070 [2]天津医科大学基础医学院

出　　处：《环境与健康杂志》2011年第11期959-961,共3页Journal of Environment and Health

基　　金：国家自然科学基金青年基金(30800954)

摘　　要：目的研究缺铁性贫血对大鼠甲状腺功能的影响,以期为铁缺乏地区的碘缺乏病防治工作提供新的线索和思路。方法选择健康SPF-VAF级初断乳SD雄性大鼠30只,按体质量随机分为对照组(饲料平均含铁量为93.3mg/kg)和缺铁性贫血组(饲料平均含铁量为9.6 mg/kg),每组15只。喂养6周后,测定大鼠体质量和甲状腺质量,并计算甲状腺相对质量。取大鼠全血并分离血清,采用生化法检测血红蛋白、血清铁水平和总铁结合力;以化学发光法检测血清总三碘甲腺原氨酸(TT3)、游离三碘甲腺原氨酸(FT3)、总甲状腺素(TT4)、游离甲状腺素(FT4)和促甲状腺激素(TSH)水平。结果缺铁性贫血组大鼠体质量比对照组减轻(P<0.01),两组间甲状腺绝对质量和相对质量均未见统计学差异。缺铁性贫血组大鼠血红蛋白水平和血清铁水平比对照组降低(P均<0.01),总铁结合力比对照组升高(P<0.01)。缺铁性贫血组大鼠TT3、TT4、FT3和FT4均较对照组降低(P均<0.01)。结论缺铁性贫血可导致甲状腺功能减低,铁缺乏地区碘缺乏病防治过程中应同时注意人群铁营养状态,对缺铁个体进行铁营养补充。Objective To explore the effect of iron deficiency anemia on thyroid function in rats. Methods Thirty healthy SPF/VAF level weaning SD male rats were randomly divided into control group （iron content in diet was 93.3 mg/kg） and iron deficiency anemia group （iron content in diet was 9.6 mg/kg） by body weight,15 in each group. After 6 weeks of treatment, body weight and thyroid glands weight were mensurated. Hemoglobin, serum iron, total iron binding capacity;and TT3, TF4, FT3, FT4,and TSH were determined. Results Compared with control group,animals in iron deficiency anemia group had less body weight（P〈0.01 ）. Hemoglobin and serum iron in control group were higher than those in iron deficiency anemia group（ all P〈0.01）, and total iron binding capacity in iron deficiency anemia group increased significantly （P〈0.01）; at the same time ,in iron deficiency anemia group, their serum hormones TT3, TF4, FT3 and FT4 were lower than those in control group （P〈0.01）. Conclusion Iron deficiency anemia may cause hypothyroidism. The combined supplement of iodine and iron may improve the preventive effect of iodine in the iron deficiency area.

关 键 词：缺铁性贫血 甲状腺功能 大鼠 

分 类 号：R994.6[医药卫生—毒理学]