898例泌尿生殖道患者支原体感染的检测及药敏分析  

Detection and drug sensitivity analysis of Mycoplasma infection in urogenital tract in 898 Patients

作　　者：李春辉[1] 孙可歆[2] 

机构地区：[1]北华大学附属医院同位素科,吉林吉林132001 [2]吉林医药学院检验系,吉林吉林132011

出　　处：《中国热带医学》2011年第10期1265-1267,共3页China Tropical Medicine

摘　　要：目的了解2010年4月-2011年4月吉林市某医院898例泌尿生殖道感染患者进行解脲脲原体(Uu)和人型支原体(Mh)实验室检测结果进行分析,了解其感染状况及耐药性。方法解脲脲原体(Uu)和人型支原体(Mh)的分离鉴定、半定量计数和抗生素的药物敏感性试验。结果对来自898例患者的标本进行Uu和Mh体外培养,共检出阳性标本397例,阳性检出率为44.21%(397/898)。在阳性标本中,男性占18.14%(72/397),女性占81.86%(325/397),女性高于男性。其中,Uu单项感染占74.81%(297/397),Mh单项感染占3.52%(14/397),Uu和Mh混合感染占21.67%(86/397),即Uu>Uu+Mh>Mh。在这三种类型感染中,女性感染的Uu、Mh及Uu+Mh均大于男性,Uu+Mh混合感染大有增加趋势。支原体感染的年龄段21-40岁居首位。药敏结果,397例支原体(Uu、Mh、Uu+Mh)均对强力霉素、美满霉素、交沙霉素较敏感,对罗红霉素、氧氟沙星、阿奇霉素耐药率高,但与各地报告的结果也有差别。结论泌尿生殖道支原体感染以Uu感染为主,大部分细菌都产生耐药性,混合性感染的耐药更加严重。Objective To analze the infection stats and drug resistance of Ureaplasma urealyticum（Uu） and the Mycoplasma hominis（Mh） in 898 outpatients from April 2010 to April 2011 in Jilin.Methods Ureaplasma urealyticum（Uu） and Mycoplasma hominis（Mh） were detected by semi-quantitative counting and antibiotic susceptibility testing and identified with comercial culture media.Results Totally 898 specimens were cultured and tested,397 patients were infected with Mycoplasma（44.21%,397/898）.The positive rate in females was 81.86%（325/397） and 18.14%（72/397） in males.The positive rate of femalea was higher than that of malea.Most of the infections occurred to age groups of from 21 to 40 years.The simple infection rate of Uu was 74.81%（297/397） and Mh was 3.52%（14/397）,respectively.The mixed infection cases were 86 accounting for 21.67%.The sensitivity of Uu,Mh and Uu＋Mh to antibiotics from high to low were in the order of minocycline（96.9%）,doxycyclin（96.9%）,josamycine（92.2%）,and clarithromycin（87.5%）.Conclusion Uu is a common pathogen resulting in urogenital tract infection.And sensitivity tests revealed that most strains were resistant to antibiotics,suggesting that the clinical use of antibiotics should be reasonable to prevent the increase of drug-resistance and enhance curative efficacy.

关 键 词：支原体 感染 药物敏感性 

分 类 号：R375.3[医药卫生—病原生物学]