慢性乙肝患者HBeAg、PreS1-Ag与HBV-DNA的相关性  

The correlation of HBeAg,PreS1-Ag with HBV-DNA in chronic hepatitis B patients

作　　者：习浩[1] 刘荣静[1] 刘志伟 

机构地区：[1]广州医学院第二附属医院检验科,广东广州510260 [2]广州市番禺区中心医院检验科,广东广州510260

出　　处：《中国热带医学》2011年第10期1281-1282,共2页China Tropical Medicine

摘　　要：目的分析慢性乙型肝炎患者HBeAg、PreS1-Ag与HBV-DNA的相关性,探讨PreS1-Ag检测在监测慢性乙型肝炎患者病毒复制中的临床意义。方法 170例慢性乙型肝炎患者均采用酶联免疫吸附法(ELISA)检测HBV-M及PreS1-Ag,实时荧光定量聚合酶链反应(FQ-PCR)检测HBV-DNA。结果 170例慢性乙型肝炎患者中HBeAg阳性率为24.1%(41/170),PreS1-Ag阳性率为61.7%(105/170),两者阳性率具有显著的统计学差异(χ2=39.38,P<0.005),110例"小三阳"患者中PreS1-Ag阳性率达58.2%(64/110)。结论 PreS1-Ag与HBV-DNA的相关性明显优于HBeAg,是慢乙肝患者病毒复制的良好监测指标。Objective To investigate the clinical significance and correlation of HBV PreS1-Ag,HBeAg,PreS1-Ag with HBV-DNA in the chronic hepatitis B patients.Methods HBV-M,PreS1-Ag of the 170 chronic hepatitis B patients were detected by ELISA and HBV-DNA by fluorescence quanitation polymerase chain reaction（FQ-PCR）.Results In the 170 chronic hepatitis B patients,the PreS1-Ag positive rate was 61.7%（105/170）and the HBeAg positive rate was 24.1%（41/170）.There was significantly different between PreS1-Ag and HBeAg（χ2=39.38,P0.005）.In the 110 patients with HBsAg（＋）,anti-HBe（＋） and anti-HBc（＋）,the PreS1-Ag positive rate was 58.2%（110/138）.Conclusions PreS1-Ag was a good marker superior to HBeAg in reflecting the reprication of HBV,it might be very important for treatment of the chronic hepatitis B patients.

关 键 词：慢性乙型肝炎 HBV-DNA PRES1-AG 

分 类 号：R512.62[医药卫生—内科学]