EB病毒亚型／变异株及其与疾病关系的研究进展  

Advance on subtypes/variant of Epstein-Barr virus and relationship between subtypes/variants and Epstein-Barr virus related diseases

作　　者：艾军红（综述）[1] 谢正德（审校）[1] 

机构地区：[1]首都医科大学附属北京儿童医院北京市儿科研究所病毒室儿科学国家重点学科省部共建儿科重大疾病研究重点实验室,100045

出　　处：《国际儿科学杂志》2011年第6期568-571,共4页International Journal of Pediatrics

基　　金：基金项目：北京市卫生系统高层次卫生技术人才专项经费（2009-3-42）

摘　　要：Epstein—Barr病毒（Epsteir—Barrvirus，EBV）属于疱疹病毒科γ亚科，与鼻咽癌、地方性伯基特淋巴瘤和霍奇金淋巴瘤等相关，是重要的肿瘤相关病毒。EBV基因组中存在多个多态性区域，根据这些区域中氨基酸的变异，可将EBV分为不同的亚型／变异株。日前，关于不同EBV亚型／变异株与疾病间是否相关尚无定论。该文从LMP1、EBNA1、BZLF1这三个多态性区域总结了近年来关于EBV弧型／变异株与疾病表型间关系的研究进展。Epstein-Barr virus （EBV）is a ubiquitous human gamma-1 herpesvirus, which is associated with human malignancies, such as nasopharyngeal carcinoma, Burkitt＇s lymphoma and Hodgkin lymphoma. Based on the polymorphism of amino acids in the polymorphic region of EBV genome, it can be classified into different subtypes/variants. By now, whether the subtypes/variants of EBV preferentially is associated with particular malignancies or represent geographical polymorphism remains controversial. This review summarized the literature on sequence variation in EBV genes, focusing on LMP-1, EBNA-1, and BZLF-1 and their distribution by geography and disease.

关 键 词：EBV 潜伏膜蛋白1 EBV核抗原1 EBV即刻早期基因 

分 类 号：R512.8[医药卫生—内科学]