麻醉药对[Ca2＋]i的多途径改变及相关生物学效应  

Multiways of the Anesthetics to Change [Ca2＋]i and Their Related Effects

作　　者：周妙苗[1] 张诗海[1] 姚尚龙[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院麻醉科,武汉430022

出　　处：《麻醉与监护论坛》2011年第5期346-348,共3页Forum of Anesthesia and Monitoring

摘　　要：Ca2＋是细胞内的第二信使．它参与细胞内很多生理活动过程．包括神经递质释放．肌肉收缩，腺体分泌．学习记忆及细胞凋亡等。麻醉药可以通过多种方式直接或间接改变[Ca2＋]i从而对生物体产生错综复杂的影响．这些影响有些与麻醉作用有关有些与麻醉作用无关。Ca2＋ is an intracellular second message, it has been involved in versatile intracellular physiological activities, including neurotransmitter release, muscle contraction, gland secretion, learning and memory, even apoptosis, Anesthetics especially inhalational anesthetics can change [Ca2＋]i directly or indirectly in multiple ways, as a result having the organism complicatedly affected, some of the affection is related with anesthesia, but most is nothing to do with anesthesia.

关 键 词：CA2+ 吸入麻醉药 钙通道 RYANODINE受体 IP3受体 

分 类 号：R285.5[医药卫生—中药学]