吸入麻醉药的神经保护效应及可能机制  

Inhalation Anesthetics on Neuroprotective Effects and Possible Mechanism

作　　者：张俊杰（综述）[1] 郡建勤（审校）[1] 

机构地区：[1]中南大学湘雅医院麻醉科,湖南省长沙市410008

出　　处：《麻醉与监护论坛》2011年第5期359-362,共4页Forum of Anesthesia and Monitoring

摘　　要：围术期的脑缺血风险极有可能留下致命性的损伤，而自19世纪60年代人们就发现吸入麻醉药具有神经保护的潜在特质，本文主要璧点综述过去30年在临床广泛使用的以七氟烷为代表的氟烷类吸入麻醉药．他们的保护作用及可能的机制，虽然陷于操作性和安全性等因素．绝大部分的研究数据基于动物模型的体外或体内实验．但是数据依然提示吸入麻醉药对于轻中度缺血损伤具有保护价值。Cerebral ischemia during surgery can be catastrophic.While volatile anesthetic agents have been recognized for their potential neuroprotective properties since the 1960s. This review emphasizes the ether-like volatile agents that have been used clinically in the last three decades, There is ongoing research into the mechanism or mechanisms responsible for the state of general anesthesia induced by the volatile agents. Though the data are from volatile agents in cerebral ischemia in vivo, in vitro,on animal model, we can believe volatile agents have benefit in mild or moderate cerebral ischemia insult.

关 键 词：吸入麻醉药 脑缺血 保护机制 

分 类 号：R722.12[医药卫生—儿科]