89例RRTI儿童过敏原检测及脱敏治疗临床分析  

Clinical analysis of 89 cases of recurrent respiratory tract infection in children patients with aeroallergens inspect and desensitization treatment

作　　者：聂亚玲[1] 李芳[1] 于湛[2] 李士芝[1] 王艺[1] 常宏宇[1] 党小莉 张霞[1] 曾立[1] 王鹏[2] 孙奕 

机构地区：[1]第二炮兵总医院儿科,北京100088 [2]第二炮兵总医院耳鼻喉科,北京100088 [3]北京儿童福利院,100085

出　　处：《中华哮喘杂志（电子版）》2008年第3期183-185,共3页Chinese Journal of Asthma(Electronic Version)

摘　　要：目的探讨变应原在儿童反复呼吸道感染(recurrent respiratory tract infections,RRTI)发病中的作用,观察变应原脱敏治疗对控制儿童RRTI的效果。方法采用德国默克公司的阿罗格变应原检测试剂盒对89例RRTI患儿与43名健康对照儿童进行变应原筛查,对检测结果进行统计学分析。对其中14例尘螨过敏的RRTI患儿进行脱敏治疗,总疗程48～52周,完成治疗后随访1年,对比脱敏治疗前后患儿呼吸道感染的发病频次。结果89例RRTI患儿中对一种或多种变应原产生阳性反应的患儿为85例,其中产生(++)以上阳性反应的患儿为63例(70.79%);最常见的前4种变应原依次为屋尘螨41例(65.08%)、粉尘螨32例(50.7%)、杂草10例(15.8%)和霉菌8例(12.7%)。43名健康对照儿童对一种或多种变应原产生阳性反应的患儿为9例,其中产生(++)以上阳性反应的儿童为4例(9%),明显低于RRTI患儿(P<0.05)。14例完成脱敏治疗的患儿,治疗前后人均患呼吸道感染次数由(8.2±2.6)次/年下降至(3.6±1.5)次/年。结论RRTI患儿对变应原的敏感性明显高于对照组,提示变应原是诱发儿童RRTI的重要原因;对RRTI患儿进行变应原的脱敏治疗是治疗儿童RRTI的有效方法。Objective To investigate the effect of allergens in development of children recurrent respiratory tract infections(RRTI) and the effect of desensitization treatment.Methods To detect the allergens of 89 RRTI children and 43 healthy children with Aeroallergens Detection Kit (Merck),statistics analysis on detection result was provided.14 RRTI patients which respond positively to dermatophagoides pteronyssinus were given 48-52 weeks of desensitization treatment.One year follow-up visit was taken after treatment.The incidence of respiratory infection in these 14 patients after desensitization treatment was compared with that of pretherapy.Results 85 of 89 RRTI patients had positive results,and 63 cases (70.79%) had ++ and upper level.The most popular 4 allergens found in the patients was dermatophagoides pteronyssinus(65.08%),dermatophagoides farinae (50.7%),Herbs (15.8%) and mycetes (18.7%).12 of 43 healthy children control had positive results,and only 4 cases (9%) had ++ and upper level,which was significantly less than that of RRTI children(P<0.05).The per capita respiratory infection frequency of the 14 RRTI finished desensitization treatment decreased from 8.2±2.6 times per year to 3.6±1.5.Conclusion RRTI children were more sensitive to allergens than healthy control.This indicated that allergens are important factors inducing RRTI.Desensitization treatment is effective to cure RRTI.

关 键 词：反复呼吸道感染 变应原 脱敏治疗 儿童 

分 类 号：R725.6[医药卫生—儿科] R765.21[医药卫生—临床医学]