支气管哮喘患者尿液白三烯E_4测定及其临床意义  

Detection of leukotriene E_4 in the urine of patients with bronchial asthma and evaluate their clinical significance

作　　者：郭海英[1] 周新[1] 陈钦[1] 

机构地区：[1]上海交通大学附属第一人民医院呼吸科,200080

出　　处：《中华哮喘杂志（电子版）》2008年第3期200-201,共2页Chinese Journal of Asthma(Electronic Version)

摘　　要：目的探讨白三烯E4(LTE4)在支气管哮喘(简称哮喘)发病机制中的作用。方法用ELISA法对急性发作期和非急性发作期哮喘患者各20例及健康志愿者15名作尿液LTE4测定。结果哮喘急性发作组、非急性发作组尿液LTE4明显高于正常对照组(P<0.01)。哮喘急性发作组尿液LTE4值又明显高于非急性发作组(P<0.01)。哮喘非急性发作者用白三烯受体拮抗剂治疗后可使尿液LTE4水平明显降低。结论本研究结果表明白三烯在哮喘发病中起了重要的作用,检测尿液LTE4水平对于了解哮喘患者体内白三烯水平,以及评价白三烯受体拮抗剂的疗效具有一定的临床意义。Objective To explore the role of leukotriene E4(LTE4) in pathogenesis of bronchial asthma.Methods With ELISA,the levels of LTE4 was measured in the urine of 20 patients with attack asthma and 20 patients with non-attack asthma and 15 normal subjects.Results The levels of LTE4 of urine in attack asthmatics and non-attack asthmatics were significantly higher than those in normal subjects(P<0.01).The levels of LTE4 of urine in attack asthmatics were significantly higher than those in non-attack asthmatics(P<0.01).Treatment of asthma with leukotriene receptor antagonist led to a significant decrease in levels of LTE4 of urine in non-attack asthmatics.Conclusions It indicated that LT might play an important role in the pathogenetic process of the asthma,and can act as the marker of activity of the diseases.Detection of LTE4 in the urine of patients with bronchial asthma may be helpful in evaluating therapeutic effect of leukotriene receptor antagonist.

关 键 词：支气管哮喘 白三烯E₄ 

分 类 号：R562.25[医药卫生—呼吸系统]