灯盏花素亚微乳的制备及大鼠体内药动学  

Preparation of Breviscapine Submicron Emulsions and Their Pharmacokinetics in Rats

作　　者：陈洪轩[1,2] 刘万路[2] 肖衍宇[3] 

机构地区：[1]河南大学药物研究所 [2]河南大学药学院,河南开封475004 [3]中国药科大学药学院,江苏南京210009

出　　处：《中国医药工业杂志》2011年第4期285-288,共4页Chinese Journal of Pharmaceuticals

摘　　要：以高速分散-超声法制备了灯盏花素亚微乳,所得制品在透射电镜下呈圆形或椭圆形,平均粒径为(225.0±7.5)nm,ζ电位为(-42.7±1.3)mV。以灯盏花素注射剂为参比制剂,考察了灯盏花素亚微乳在大鼠体内的药动学。结果显示,灯盏花素亚微乳及其注射剂的体内过程均符合三室模型,t1/2β为214.1和47.6 min,AUC为294.8和123.7μg·ml-1.min,MRT为32.5和10.3 min。表明灯盏花素亚微乳能改变灯盏花素的体内消除行为,延长体内滞留时间。The breviscapine submicron emulsions were prepared by high-speed dispersion-ultrasonic method.The appearance of the products was spherical or elliptical,and the mean diameter was（225.0±7.5）nm with the ζ potential of（-42.7±1.3）mV.The pharmacokinetics of the breviscapine submicron emulsions in rats was investigated with breviscapine injection as the reference preparation.The results showed that the breviscapine submicron emulsions and its injection fit the three-compartment model.The pharmacokinetic parameters of breviscapine submicron emulsions and its injection were as follows： t1/2β 214.1 and 47.6 min,AUC 294.8 and 123.7 μg·ml-1·min,MRT 32.5 and 10.3 min,respectively.It was indicated that the breviscapine submicron emulsions could change elimination behavior and extend the retention time of breviscapine in rats.

关 键 词：灯盏花素 亚微乳 制备 药物动力学 

分 类 号：R944.9[医药卫生—药剂学]