Infusion of methylphenidate into the basolateral nucleus of amygdala or anterior cingulate cortex enhances fear memory consolidation in rats  

作　　者：ZHENG XinLing LIU Fang WU XingWen LI BaoMing 

机构地区：[1]Institute of Neurobiology and State Key Laboratory of Medical Neurobiology,Institutes of Brain Science,Fudan University,Shanghai 200032,China [2]Zha-Bei Central Hospital,Shanghai 200070,China [3]Department of Biology,Huaibei Coal Industry Teachers College,Anhui 235000,China

出　　处：《Science China(Life Sciences)》2008年第9期808-813,共6页中国科学（生命科学英文版）

基　　金：Supported by the Ministry of Science and Technology of China(Grant Nos.2006CB500807 and 2006AA02Z199);the Ministry of Education of China(Program for Changjiang Scholars and Innovative Research Team in University);the National Natural Science Foundation of China(Grant Nos.30225023,30430240 and 30611120530)

摘　　要：The psychostimulant methylphenidate (MPD; also called Ritalin) is a blocker of dopamine and norepi-nephrine transporter. It has been clinically used for treatment of Attention Deficit and Hyperactivity Disorder (ADHD). There have been inconsistent reports regarding the effects of systemically adminis-tered MPD on learning and memory, either in animals or humans. In the present study, we investigated the effect of direct infusion of MPD into the basolateral nucleus of amygdala (BLA) or the anterior cin-gulate cortex (ACC) on conditioned fear memory. Rats were trained on a one-trial step-through inhibi-tory avoidance task. MPD was infused bilaterally into the BLA or the ACC, either at ‘0’ or 6 h post-training. Saline was administered as control. Memory retention was tested 48 h post-training. In-tra-BLA or intra-ACC infusion of MPD ‘0’ h but not 6 h post-training significantly improved 48-h memory retention: the MPD-treated rats had significant longer step-through latency than controls. The present results indicate that action of MPD in the BLA or the ACC produces a beneficial effect on the consoli-dation of inhibitory avoidance memory.The psychostimulant methylphenidate (MPD; also called Ritalin) is a blocker of dopamine and norepi-nephrine transporter. It has been clinically used for treatment of Attention Deficit and Hyperactivity Disorder (ADHD). There have been inconsistent reports regarding the effects of systemically adminis-tered MPD on learning and memory, either in animals or humans. In the present study, we investigated the effect of direct infusion of MPD into the basolateral nucleus of amygdala (BLA) or the anterior cin-gulate cortex (ACC) on conditioned fear memory. Rats were trained on a one-trial step-through inhibi-tory avoidance task. MPD was infused bilaterally into the BLA or the ACC, either at ‘0’ or 6 h post-training. Saline was administered as control. Memory retention was tested 48 h post-training. In-tra-BLA or intra-ACC infusion of MPD ‘0’ h but not 6 h post-training significantly improved 48-h memory retention: the MPD-treated rats had significant longer step-through latency than controls. The present results indicate that action of MPD in the BLA or the ACC produces a beneficial effect on the consoli-dation of inhibitory avoidance memory.

关 键 词：METHYLPHENIDATE RITALIN basolateral nucleus of amygdala anterior cingulate cortex fear memory rat 

分 类 号：Q4[生物学—生理学]