A novel cell subset:Interferon-producing killer dendritic cells  

作　　者：WANG JiongKun & XING FeiYue Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China 

出　　处：《Science China(Life Sciences)》2008年第8期671-675,共5页中国科学（生命科学英文版）

基　　金：the National Natural Science Foundation of China (Grant No. 30471635);Natural Science Foundation of Guangdong Province in China (Grant Nos. 04010451 and 5006033)

摘　　要：Recent reports introduce a novel cell subset of DCs with antigenic phenotypes shared by both NK cells and B cells, but without surface markers of pDCs and T cells, appearing to be a chimera of NK cells and DCs, namely interferon-producing killer dendritic cells(IKDCs).IKDCs not only secret type I and type II interferons to recognize and kill tumor cells effectively, but also express MHC-II molecules to present antigens.Thus, IKDCs are considered as important immunosurveilance cells for tumors, providing a link between innate and adaptive immunity.Recent reports introduce a novel cell subset of DCs with antigenic phenotypes shared by both NK cells and B cells, but without surface markers of pDCs and T cells, appearing to be a chimera of NK cells and DCs, namely interferon-producing killer dendritic cells(IKDCs).IKDCs not only secret type I and type II interferons to recognize and kill tumor cells effectively, but also express MHC-II molecules to present antigens.Thus, IKDCs are considered as important immunosurveilance cells for tumors, providing a link between innate and adaptive immunity.

关 键 词：IKDCs cDCs pDCs NK CELLS 

分 类 号：R392[医药卫生—免疫学]