PdCl_2-catalyzed heterocyclotrimerization in MeOH/scCO_2:A versatile approach to dimethyl pyridine-3,5-dicarboxylate from methyl acrylate and urea  

作　　者：ZOU Bo,JIANG HuanFeng College of Chemistry,South China University of Technology,Guangzhou 510640,China 

出　　处：《Science China Chemistry》2008年第5期447-451,共5页中国科学（化学英文版）

基　　金：the National Natural Science Foundation of China (Grant Nos. 20332030, 20572027, 20625205 and 20772034);Guangdong Natural Science Foundation (Grant No. 07118070)

摘　　要：A novel and green method for the synthesis of dimethyl pyridine-3,5-dicarboxylate has been developed. It is PdCl2-catalyzed heterocyclotrimerization of methyl acrylate with urea in methanol/supercritical carbon dioxide. The target compound was obtained with a 75% isolated yield under the optimized con-ditions.A novel and green method for the synthesis of dimethyl pyridine-3,5-dicarboxylate has been developed. It is PdCl2-catalyzed heterocyclotrimerization of methyl acrylate with urea in methanol/supercritical carbon dioxide. The target compound was obtained with a 75% isolated yield under the optimized con-ditions.

关 键 词：PDCL2 heterocyclotrimerization DIMETHYL pyridine-3 5-dicarboxylate scCO2 

分 类 号：O643.36[理学—物理化学]