血尿酸与高血压病的关系研究  

Serum uric acid is notan independent risk factor hypertertion

作　　者：刘俊伏[1] 赵勇军[1] 张刚[1] 

机构地区：[1]河北省老年病医院,石家庄050011

出　　处：《中国实用内科杂志》2008年第S2期103-104,共2页Chinese Journal of Practical Internal Medicine

摘　　要：目的探讨血尿酸浓度升高是否为高血压的独立预测因子。方法对河北省老年病医院心内科2007年9月至2008年2月住院患者临床资料进行回顾性分析,选择根据2005年WHO高血压病诊断标准确诊为高血压病患者128例(1级高血压26例,2级高血压46例,3级高血压56例),年龄65(64.49±11.03)岁,其中男99例、女29例;同期血压正常的连续性入院患者87例作为对照组,年龄62(61.25±10.98)岁,其中男53例、女34例。入院第2天清晨取空腹12h抽取静脉血进行血尿酸、血脂等各种生化检查,详细询问包括吸烟、冠心病、糖尿病等病史。入院期间进行动态血压监测。结果高血压组血尿酸浓度高于对照组[(496.31±42.33)μmol/L对(356.08±50.68)μmol/L,P<0.01],且随着血压的升高血尿酸浓度及高尿酸血症比例也随之增高。但Logistic回归分析显示血尿酸并非高血压病的独立危险因素。结论血尿酸浓度升高可能只是高血压病的一个标志,而非高血压病的独立危险因素。Objective To determine whether the raised serum uric acid(UA) level is the tindependent risk factor Hypertension.Methods A retrospective study was performed including 128 Hypertension patients(male 99,female 29) with average age of(64.49±11.03) and 87 norma Hypertension patients(male 53,female 34) with average age of(61.25±10.98) .A fasting blood samp les were collected for measurement of serum UA,blood cholesterol,and so on. And all patients were carefully inquired for their history including smoking、forcoronary artery disease and DM.Results Althoughraised serum UA was observed in Hypertension patients(496.31±42.33) mmol/L vs(356.08±50.68) mmol/L(P<0.01) ,logistic analysis suggested serum UA was not an independent risk factor for Hypertension.Conclusion The raised serum UA may be a marker of atherosclerosis and is notan independent p redictor for Hypertension.

关 键 词：血尿酸 高血压 危险因素 

分 类 号：R544.1[医药卫生—心血管疾病]