LC-MS/MS法对卷烟主流烟气中8种羰基化合物的测定  

Determination of 8 Volatile Carbonyls in Mainstream Cigarette Smoke with LC-MS/MS

作　　者：郭磊 索卫国 田耀伟 廖堃 

机构地区：[1]江西中烟工业公司技术中心,江西南昌330096

出　　处：《分析测试学报》2008年第S1期99-102,共4页Journal of Instrumental Analysis

摘　　要：A liquid chromatography-tandem mass spectroscopy(LC-MS/MS)method was developed for analysis of carbonyl compounds in cigarette mainstream smoke.The cigarette smoke was collected using a Cambridge filter treated with acidic solution of 2,4-dinitrophenylhydrazine,then extracted with acetonitrile.The extract was diluted with acetonitrile-water and analyzed by LC-MS/MS in negative electro-spray ionization mode.Formaldehyde,acetaldehyde,acetone,acrolein,propionaldehyde,methyl ethyl ketone,butyraldehyde and crotonaldehyde in mainstream cigarette smoke were analyzed with the recovery at the range of 83% to 103%.The minimum detectable quantity for the carbonyls ranged from 0.08 to 0.28 μg/L,and relative standard deviations were below 6%.This new method had higher selectivity and sensitivity compared to conventional methods.5 kinds of foreign and domestic cigarette were analyzed.A liquid chromatography-tandem mass spectroscopy(LC-MS/MS)method was developed for analysis of carbonyl compounds in cigarette mainstream smoke.The cigarette smoke was collected using a Cambridge filter treated with acidic solution of 2,4-dinitrophenylhydrazine,then extracted with acetonitrile.The extract was diluted with acetonitrile-water and analyzed by LC-MS/MS in negative electro-spray ionization mode.Formaldehyde,acetaldehyde,acetone,acrolein,propionaldehyde,methyl ethyl ketone,butyraldehyde and crotonaldehyde in mainstream cigarette smoke were analyzed with the recovery at the range of 83% to 103%.The minimum detectable quantity for the carbonyls ranged from 0.08 to 0.28 μg/L,and relative standard deviations were below 6%.This new method had higher selectivity and sensitivity compared to conventional methods.5 kinds of foreign and domestic cigarette were analyzed.

关 键 词：CARBONYLS MAINSTREAM CIGARETTE SMOKE DNPH LC-MS/MS 

分 类 号：TS47[农业科学—烟草工业]