阻塞性睡眠呼吸暂停低通气综合征与氧化抗氧化相关性研究  

Correlational Study of Oxidation,Antioxidation and Obstructive Sleep Apnea Hypopnea Syndrome

作　　者：高爱武[1] 高淑磊 韩丽娟[1] 平芬[3] 李琪[3] 田玉静[1] 

机构地区：[1]河北省保定市第二医院呼吸科,071000 [2]保定市第四医院 [3]河北省人民医院

出　　处：《职业与健康》2011年第22期2521-2524,共4页Occupation and Health

摘　　要：目的观察阻塞性睡眠呼吸暂停低通气综合征(Obstructive Sleep Apnea-hypopnea Syndrome,OSAHS)患者及OSAHS相关高血压(OSAHAHT)患者血清中氧化低密度脂蛋白(oxidized low density lipoprotein,ox-LDL)及铜锌超氧化物歧化酶(copper-zinc superoxide dismutase,CuZnSOD)水平的变化。方法选择OSAHS及OSAHAHT患者各20例及健康对照组20例,应用酶联免疫吸附试验检测血清中ox-LDL水平,用黄嘌呤氧化酶法检测血清中CuZnSOD水平,并与睡眠监测指标进行相关分析。结果与对照组比较,OSAHS及OSAHAHT组患者血清中ox-LDL浓度升高,CuZnSOD浓度降低(P<0.01),差异有统计学意义(P<0.01)。OSAHS及OSAHAHT组患者血清中ox-LDL、CuZnSOD水平与反映睡眠呼吸暂停严重程度的指标有相关性(P<0.01)。结论 OSAHS及OSAHAHT患者血清中ox-LDL及CuZnSOD水平有变化,存在氧化应激,血清中ox-LDL及CuZnSOD水平可以反映OSAHS患者的病情严重程度。[Objective]To observe the changes of serum oxidized low density lipoprotein（ox-LDL） and serum copper-zinc superoxide dismutase（CuZnSOD）in patients with obstructive sleep apnea-hypopnea syndrome（OSAHS） and obstructive sleep apnea-hypopnea associated hypertension（OSAHAHT）. [Methods]A total of 20 OSAHS patients,20 OSAHAHT patients and 20 health controls were selected.Serum ox-LDL level and CuZnSOD level was determined by enzyme-linked immunosorbent assay and xanthine oxidase,respectively.And they were comparatively analyzed with the indexes of polysomnography [Results]The serum levels of ox-LDL were higher and the serum levels of CuZnSOD were lower in pateints with OSAHS and OSAHAHT when compared with those in control group（P0.01）.The serum ox-LDL and CuZnSOD levels in patients with OSAHS and OSAHAHT were correlated with the indexes of polysomnography which reflected the severity of obstructive sleep apnea（P0.05）. [Conclusion]Serum ox-LDL and CuZnSOD levels change in patients with OSAHS and OSAHAHT,and they may correlat with the severity of the disease.The oxydative stress process exists in the patients with OSAHAHT.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 氧化低密度脂蛋白 铜锌超氧化物歧化酶 高血压 氧化抗氧化 

分 类 号：R563.9[医药卫生—呼吸系统]