临沂市新生儿接种乙型肝炎疫苗后免疫效果观察  

Observation of Immune Effect of Hepatitis B Vaccine on Newborn Babies in Linyi City

作　　者：辛崇干[1] 

机构地区：[1]山东省临沂市疾病预防控制中心,276000

出　　处：《职业与健康》2011年第22期2540-2542,共3页Occupation and Health

基　　金：临沂市2010年科学技术发展计划项目(项目编号:201013075)

摘　　要：目的观察新生儿接种重组酵母乙型肝炎疫苗(简称乙肝疫苗)后的免疫持久性及阻断乙型肝炎病毒(HBV)母婴传播的效果。方法应用放射免疫法(RIA)检测HBV血清标志物HBsAg、HBeAg和抗-HBs。结果新生儿在其免后1、3、5、8、10年,HBsAg阳性率分别为0.93%、0.98%、0.63%、1.15%和1.35%,平均为0.99%,抗-HBs阳性率分别为92.13%、81.98%、71.25%、65.58%和47.17%,平均为73.16%;母亲HBsAg单阳性组和HBsAg、HBeAg双阳性组抗-HBs阳性率分别为91.11%、90.14%,母婴传播阻断率分别为97.39%、90.06%。结论新生儿接种乙肝疫苗后具有较强的免疫持久性,应用10μg×3接种方案阻断HBV母婴传播效果良好。[Objective]To observe the protective efficacy in preventing maternal-infant transmission of Hepatitis B Virus（HBV） and immune persistence of recombinant yeast derived hepatitis B vaccines（HepB）. [Methods]HBsAg,HBeAg and Anti-HBs in blood samples were detected by using RIA method. [Results]The results of the research showed that after 1,3,5,8 and 10 years of immunization,the positive rate of HBsAg was 0.93%,0.98%,0.63%,1.15% and 1.35% respectively,the average value was 0.99%.the positive rate of anti-HBs was 92.13%,81.98%,71.25%,65.58% and 47.17% respectively,the average value was 73.16%.The positive rate of anti-HBs of mother HBsAg single positive group and HBsAg and HBeAg double positive group was 91.11%,90.14% respectively and the protective rate was 97.39%,90.06% respectively. [Conclusion]HepB showed good immunogenicity and immune persistence on newborns,10ug×3 HepB plan can prevent Maternal-infant transmission of HBV effectively.

关 键 词：重组酵母乙型肝炎疫苗 免疫持久性 母婴阻断 

分 类 号：R186[医药卫生—流行病学]