ACEI/D基因多态性与武汉地区原发性高血压代谢综合征关系的探讨  

Relationship between metabolic syndrome and ACE I/D gene polymorphisms in hypertensive patience of wuhan chinese

作　　者：何峰容[1] 程欣[2] 沈关心[3] 王夜明[1] 

机构地区：[1]湖北省新华医院检验科,武汉430022 [2]华中科技大学同济医学院附属协和医院 [3]华中科技大学同济医学院免疫学系

出　　处：《临床血液学杂志（输血与检验）》2007年第6期254-256,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

基　　金：湖北省卫生厅资助项目(No:JX1B139)

摘　　要：目的:探讨武汉地区原发性高血压(EH)代谢综合征(MS)与血管紧张素转换酶(ACE)基因插入/缺失(I/D)多态性的关系。方法:701例武汉地区汉族人群分为3组,其中血压正常对照组303人,EH患者398例,其中EH患者中符合代谢综合征者189例,不伴随代谢综合组209例。应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)法测定3组人群中ACEI/D基因多态性。结果:①ACE各基因型频率在正常对照组与EH(包括MS与非MS组)组间差异无统计学意义;②ACEII基因型EH合并MS患者的胆固醇水平明显高于DD基因型。结论:ACE基因多态性与武汉地区原发性高血压无关,但D等位基因频率明显低于某些西方国家人群;对于EH合并代谢综合征的患者,其胆固醇水平和ACEII基因型明显相关。Objective:The present study was designed to investigate the association of polymorphisms of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) in essential hypertension (EH) patients affected MS or not.Method: 701 Wuhan Chinese subjects were grouped into three teams, those were 303 normotensive, 189 and 209 hypertensive cases with or without MS, respectively. The polymorphisms were detected by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) with the genomic DNA samples.Result:By statistical analysis, no significant association was identified between ACE genetic polymorphisms and either MS or EH in Wuhan population. But MS patients with II genotype of ACE had a higher concentration of cholesterol.Conclusion: ACE II genotype is related to cholesterol in MS patients.

关 键 词：原发性高血压 代谢综合征 血管紧张素转换酶 基因多态性 

分 类 号：R544.1[医药卫生—心血管疾病] R589[医药卫生—内科学]