去白细胞血小板悬液的质量检测及其临床应用  

Quality detection and its clinic application of leucocyte-poor platelet concentrate

作　　者：杨世明[1] 张勇萍[1] 杜润家[1] 田榆[1] 费红毅[1] 

机构地区：[1]第四军医大学唐都医院输血科,西安710038

出　　处：《临床血液学杂志（输血与检验）》2007年第5期198-200,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:观察FTS-PL型过滤器对机采血小板悬液中白细胞的去除率与临床应用疗效。方法:检测去白细胞前后血小板的回收率,白细胞及红细胞的残余量,对患者输注血小板悬液后的血小板上升值和临床应用疗效进行检测与观察。结果:去白细胞机采血小板悬液中血小板含量为(2.9±0.2)×1011/袋,血小板回收率达93.0%,白细胞的去除率达到99.8%;输注去白细胞机采血小板悬液患者非溶血性发热输血反应(NHFTR)率0.8%和血小板输注无效率1.6%,均低于输注未去白细胞机采血小板悬液患者的5.6%和9.5%(P<0.01)。结论:机采血小板悬液经FTS-PL型白细胞滤器过滤后,血小板质量符合"血站基本标准"要求,可明显降低NHFTR和血小板输注无效的发生率。Objective:To observe the filtration effect of the FTS-PL type filter designed to filtrate away the leucocytes from machine collecting platelet concentrate,and evaluate the clinical effect of it.Methods:The percentage platelet recovery,and the remnant amount of leucocytes and erythrocytes were detected in platelet concentrates before and after filtrating leucocytes respectively.Meanwhile,the increase value of platelets in patients with platelet transfusion was measured and evaluated.Results:The platelet concentration in machine collecting leucocyte-poor platelet concentrate was(2.9±0.2)×1011 per pounch,and percentage platelet recovery was 93%,the clearance rate of leucocytes was 99.8%.The incidence rate of non-haemolytic febrile transfusion reaction(NHFTR)and platelet transfusion refractoriness were 0.8% and 1.6% respectively in patients with leucocyte-poor platelet concentrate transfusion,both were lower than those in patients with platelet concentrate with leucocytes transfusion,5.6% and 9.5% respectively(P<0.01).Conclusion:The quality of machine collecting platelet concentrate filtrated with FTS-PL type filter to clear leucocytes accords with basic standards of blood center,and this type of platelet suspension can significantly decrease the incidence rate of NHFTR and platelet transfusion refractoriness.

关 键 词：去除白细胞 血小板悬液/机器单采 血小板输注无效 输血反应 

分 类 号：R457.1[医药卫生—治疗学]