不同肝炎患者及献血员中SENV-D/H感染流行病学调查  

Prevalence of SEN virus D and H subtype infection in different types of hepatitis and blood donors

作　　者：陈蕤[1] 穆士杰[1] 张献清[1] 安群星[1] 吴原茹[1] 

机构地区：[1]西安第四军医大学西京医院输血科,西安710032

出　　处：《临床血液学杂志（输血与检验）》2007年第5期201-203,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:了解SEN病毒D/H亚型在不同肝炎患者和献血员中的感染情况。方法:采用巢式聚合酶链反应对收集的健康献血者和各型肝炎患者进行SENV-D亚型和H亚型DNA检测。结果:无偿献血者中SENV-D的感染率为25.9%,SENV-H为24.4%;急性甲肝患者中SENV-D的感染率为14.5%,SENV-H为32.7%;慢性乙肝患者中SENV-D的感染率为46%,SENV-H为45.2%;在丙肝患者中SENV-D和SENV-H的感染率均为65%;在非甲-非戊型肝炎患者中SENV-D的感染率为51.2%,SENV-H为43.9%。结论:SENV可能与HCV和HBV具有一样的传播方式。Objective:To investigate the prevalence of SENV-D/H in different types of hepatitis and blood donors.Methods:The SENV-D/H subtype DNA were detected in 754 different hepatitis and blood donors in China by nested PCR.Results:The SENV-D/H positive rates in healthy donors were 25.9% and 24.4%,14.5% and 32.7% in acute hepatitis A patients,46% and 45.2% in chronic hepatitis B patients,both 65% in hepatitis C patients,51.2% and 43.9% in hepatitis non A-E patients.Conclusion:SENV probably has the same way of transmission as HCV and HBV.

关 键 词：SENV-D亚型 SENV-H亚型 流行病学 巢式聚合酶链反应 

分 类 号：R512.6[医药卫生—内科学]