血浆总同型半胱氨酸水平及与2型糖尿病肾病的关系  

Relationship between plasma total homocysteic acid level and type 2 diabetic nephropathy

作　　者：吕晓华 肖玉娴 

机构地区：[1]长航总医院检验科,武汉430010 [2]长航总医院神经科

出　　处：《临床血液学杂志（输血与检验）》2007年第3期106-107,110,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:研究2型糖尿病(T2DM)患者血浆总同型半胱氨酸(tHcy)水平的变化及与糖尿病肾病(DN)的关系。方法:将109例2型糖尿病患者分为正常蛋白尿组(A组,42例)、微量蛋白尿组(B组,36例)和大量蛋白尿组(C组,31例)3组,分别检测其血浆tHcy水平,并与对照组(78例)比较。结果:与对照组比较,T2DM患者血浆tHcy水平显著升高(P<0.01)。B组、C组与A组比较及B组与C组比较,tHcy均升高,差异有统计学意义(P<0.01)。T2DM患者tHcy水平的升高与尿白蛋白排泄率(UAER)呈正相关(r=0.389,P<0.01)。结论:T2DM患者的tHcy水平升高,并随着肾脏损害的加重而逐步升高。tHcy水平增高可能是糖尿病肾病的一个新的危险因素。Objective:To investigate the relationship between plasma total homocysteic acid level and type 2 diabetic nephropathy. Methods:109 type 2 diabetic patients were classified into three groups: normal proteinuria group of 42 cases (group A), microalbuminuria group of 36 cases (group B) and high-grade proteinuria group of 31 cases(group C). The plasma total homocysteic acid levels of all patients and control group of 78 healthy persons were detected. to evaluate the relationship between UAER and plasma total homocystein levels. Then the results of three experiment groups were compared to that of control group, respectively.Results:Mean total plasma homocysteic acid levels of three experiment groups were significantly higher than that of control group (P<0.01) and the level of group C was the highest of all groups.There were significant differences among group B、group C and group A (P<0.01), and between group B and group C (P<0.01). There was a positive correlation between plasma total homocysteic acid level and UREA (r=0.389,P<0.01) .Conclusion:With total homocysteic acid level increased, nephropathy in type 2 diabetic patient would be severe. Hyperhomocysteinemia may be a new risk factor for diabetic nephropathy.

关 键 词：糖尿病肾病 总同型半胱氨酸 微量白蛋白 

分 类 号：R587.2[医药卫生—内分泌]