苦荞颗粒冲剂抗氧化活性研究  

Study on Antioxidation Effects of Tartary Buckwheat Power Medicine on the D-gal Induced Aged Mice

作　　者：马挺军[1] 陕方[2] 贾昌喜[1] 

机构地区：[1]北京农学院食品科学学院,北京102206 [2]山西省农业科学院农产品综合利用研究所,太原030031

出　　处：《中国粮油学报》2011年第7期99-102,共4页Journal of the Chinese Cereals and Oils Association

基　　金："十一五"国家科技支撑计划(2006BAD02B06);北京市农产品加工及贮藏工程重点建设学科项目(PXM2009_014207_078172);北京市科技新星项目(2007B030)

摘　　要：研究苦荞颗粒冲剂(TBPM)对D-半乳糖诱导衰老小鼠氧化应激状态的影响及其作用机理。将健康的昆明雄小鼠随机分为对照组、模型组、和苦荞颗粒冲剂1号低、中、高3个剂量组与苦荞颗粒冲剂2号中剂量组。饲养6周后,测定不同剂量苦荞颗粒冲剂对小鼠抗氧化酶活性、脂质过氧化产物丙二醛含量的影响。结果表明,摄入苦荞颗粒冲剂2号后小鼠血清和肝脏中的SOD酶活显著增加(P<0.01),肝脏GSH-px活力增加(P<0.001);摄入苦荞颗粒冲剂1号高剂量后小鼠肝脏中丙二醛的含量减少,血清和肝脏中SOD酶活显著增加(P<0.05)。苦荞颗粒冲剂具有一定的抗氧化活性。To study the antioxidant effect of tartary buckwheat power medicine（TBPM）,the effect and mechanism of TBPM on oxidation were investigated by using D-galactose induced aged mice.Male KM mice（77） were divided into seven groups,saying the control group,the model group,three dosage groups with low,middle and high TBPM 1#,and the dosage group with TBPM 2#.After being fed respectively for six weeks,the effect of the different dosage of TBPM on antioxidation enzyme activity and malondialdehyde content of the mice were determined.The results showed that the intaking of TBPM Sample 2 significantly enhanced the activities of SOD in serum and liver（P〈0.01） and GSH-px in liver（P〈0.001） for the mice;the intaking of Sample 1 reduced liver malondialdehyde amount and enhanced the activities of SOD in serum and liver（P〈0.05）.It is demonstrated that TBPM has remarkable antioxidation effects on aged mice.

关 键 词：苦荞颗粒冲剂 抗氧化 D-半乳糖 

分 类 号：R587.1[医药卫生—内分泌]