磺丁基醚-β-环糊精对药物的增溶作用  

Pharmaceutical applications of sulfobutyl ether-β-cyclodextrin for solubilization

作　　者：刘春冬[1] 王建华[1] 徐世荣[1] 

机构地区：[1]重庆大学生物工程学院,重庆400044

出　　处：《中国现代应用药学》2006年第S2期742-745,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：重庆市应用基础研究项目[2003]7974

摘　　要：目的介绍磺丁基醚-β-环糊精(SBE-β-CD)对药物的增溶作用。方法分析近年来相关文献资料,对SBE-β-CD的理化性质、对药物的增溶作用以及发展趋势进行归纳总结。结果和结论SBE-β-CD对药物具有很好的增溶作用,是一种优异的新型药物辅料,具有广阔的发展前景。OBJECTIVE To review the applications of sulfobutyl ether-β-cyclodextrin(SBE-β-CD) for the solubilization of drug.METHODS Based on the results of this subject from the recent literatures,the general properties of SBE-β-CD,the effect of solubilization of drug and the trends in its development were summarized and evaluated. RESULTS AND CONCLUTION SBE-β-CD has many virtues as a pharmaceutical excipient for solubilization and the development of SBE-β-CD has a bright future.

关 键 词：磺丁基醚-Β-环糊精 溶解性 包合物 

分 类 号：R94[医药卫生—药剂学]