Excel规划求解法计算静脉滴注给药的药动学参数  

Finding Out the Optimum Solution of Pharmacokinetic Parameters of Intravenous Guttae Administration with Program Solution on Excel

作　　者：郁引飞[1] 苏银法[2] 杜乐燕[3] 

机构地区：[1]温州医学院附属眼视光医院,浙江温州325000 [2]温州市第二人民医院,浙江温州325000 [3]浙江温州医学院附属第一医院,浙江温州325000

出　　处：《中国现代应用药学》2006年第S2期777-779,共3页Chinese Journal of Modern Applied Pharmacy

基　　金：温州市科技局资助项目(Y2003A075)

摘　　要：目的建立一种简便的静脉滴注给药的药动学参数求解方法。方法Excel规划求解结合误差最小二乘法。结果通过实例分析阐明了静脉滴注给药药动学参数的计算方法,给出混杂参数A1、A2、α、β。结论Excel规划求解可在一定约束条件下获得参数的最优解,是获取静脉滴注给药的药动学参数的有效方法。OBJECTIVE To establish a convenient method to be used for obtaining the optimum solution of pharmacokinetic parameters of intravenous guttae administration with Program Solution.METHODS program solution(PS) of Microsoft Excel was used to find out the optimum solution of multivariable pharmacokinetic parameters. RESULTS Through an example,the powerful function with Excel software to find out the optimum solution of multivariable pharmacokinetic parameters was shown.The accurate solution was obtained.CONCLUSION Computational results indicated that PS is an effective method solving multivariable pharmacokinetic parameters.

关 键 词：药动学 EXCEL软件 参数 规划求解 静脉滴注 

分 类 号：R96[医药卫生—药理学]