维甲酸包合物稳定性研究  

Study on the stability of tretinoin inclusion compound

作　　者：张碧玫[1] 孙丽坤[2] 

机构地区：[1]天津医科大学总医院药剂科,天津300052 [2]天津医科大学药学院,实习生天津300203

出　　处：《中国现代应用药学》2006年第S2期780-781,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的研究维甲酸-β-环糊精的稳定性。方法以维甲酸含量为指标,分别对包合物和混合物进行抗热、抗光照、抗氧化实验。结果包合物中维甲酸含量在高温、光照、氧化条件下没有明显变化,而混合物中维甲酸含量有明显影响。结论维甲酸包合物在抗热、抗氧化、抗光照方面均优于混合物。OBJECTIVE To study the stability of tretinoin inclusion compound.METHODS We used the content of tretinoin as an index and made a set of tests on high temperature and shine and oxidation with inclusion and mixture. RESULTS Under the conditions of heat and shine and OXidation,the content of tretinoin in inclusion compound was not changed,whereas in mixture,the content was decreased.CONCLUSION The tests suggested that inclusion i S superior to mixture on the abi l ity of anti-heat,anti-oxidation and anti-shine.

关 键 词：维甲酸 包合物 稳定性 

分 类 号：R927.11[医药卫生—药学]