高效液相色谱法测定盐酸奈福泮缓释片的含量  

Determination of Nefopam Hydrochloride Sustained-release tablets by HPLC

作　　者：冯淑华[1] 张庆伟[2] 庞淑婉 

机构地区：[1]北京联合大学生物化工学院,北京100023 [2]天津医科大学药学院,天津200070

出　　处：《中国现代应用药学》2006年第S3期904-905,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的建立盐酸奈福泮(1)缓释片含量的方法;方法采用反相HPLC法,用ODS C18(250mm×4.6mm,5μm)色谱柱进行测定;结果:以甲醇-0.3%磷酸水溶液(45∶55)为流动相,检测波长为215nm,(1)在2.0~64.0μg/mL范围内呈良好的线性关系(r=0.9996);平均回收率为99.67%,RSD=0.29%;结论采用反相HPLC测定盐酸奈福泮缓释片含量,方法简便,灵敏度高,可作为(1)缓释片的质量控制方法。OBJECTIVE To establish A method for the determination of content of nefopam hydrochloride(1)sustained-release tablets;METHODS The HPLC was used with ODS C18(250mm×4.6mm,5μm); RESULTS Methanol-0.3% phosphoric acid(45∶55)was used as mobile phase,the standard curve of(1) wse linear in the concentration rang of 2.0~64.0μg/mL(r=0.9996).The average recoveries was 99.67%,RSD=0.29%;CONCLUSION The HPLC is a convenient and delicate method with which the content of(1) was determined.

关 键 词：盐酸奈福泮 高效液相色谱 缓释 

分 类 号：R927[医药卫生—药学]