双波长分光光度法测定复方地氯霜中氯霉素的含量  

Determination of chloramphenicol in Dexamethasone and Chloramphenicol Compound Cream by Dual-Wavelength Spectrophotometry

作　　者：卢今 柳涌[1] 

机构地区：[1]安徽医科大学附属省立医院药剂科,安徽合肥230001

出　　处：《中国现代应用药学》2006年第S3期912-913,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的建立复方地氯霜中氯霉素的含量测定方法。方法采用双波长分光光度法测定氯霉素的含量。选择测定波长为268nm,参比波长为248nm。结果氯霉素的平均回收率为104.3%,RSD为2.93%(n=6)。结论该方法简便、准确,适用于该制剂的质量控制。OBJECTIVE To establish a method for the determination of chloramphenicol in dexamethasone and chloramphenicol compound cream.METHODS A dual-wavelength spectrophotometry was used.The selected determining wavelength was 268nm and the reference wavelength was 248nm. RESULTS The average recovery of chloramphenicol was 104.3%,RSD=2.93%(n=6).CONCLUSION This method is simple,accurate and suitable for assay of the preparation.

关 键 词：双波长分光光度法 氯霉素 

分 类 号：R927[医药卫生—药学]