母源性抗体抗病毒性疾病研究进展  

Progress in Maternal Antibody Against Viral Disease in Infants

作　　者：张风华[1] 方芳[1] 陈则[1,2] 

机构地区：[1]湖南师范大学生命科学学院,中国湖南长沙410081 [2]中国科学院,武汉病毒研究所

出　　处：《生命科学研究》2005年第S2期105-109,共5页Life Science Research

基　　金：国家自然科学基金(C01010801);863资助项目(2001AA213051)

摘　　要：母源性抗体能够保护新生儿和婴幼儿早期抵御多种病毒的感染,但它也严重抑制婴幼儿疫苗接种后主动免疫应答的建立．母源性抗体降至失去有效保护作用但又足以抑制婴幼儿对疫苗的免疫应答这样一段时期是婴幼儿病毒性疾病的易感期．目前有多种解释试图阐明母源性抗体抑制作用的机理．综述了近年来母源性抗体及其在抗病毒性疾病中的相关研究结果,主要从母源性抗体的传递途径、母源性抗体保护新生儿和婴幼儿早期抗病毒感染、母源性抗体对婴幼儿疫苗接种后主动免疫应答的影响以及母源性抗体抑制婴幼儿主动免疫应答机理假说等方面进行阐述．Maternal antibody is the major form of protection against infectious diseases in e^ly life when the neonatal immune system is still immature;however,the presence of maternal antibody also interferes with active immunization.A window of time exists when maternal antibody levels are too low to reliably protect an infant from infectious diseases but are high enough to prevent responses to vaccines.Several explanations have been put forward to elucidate the inhibition phenomenon mediated by maternal antibody.Researches on maternal antibody against viral disease including maternal antibody transport,protective effect,inhibitory effect and mechanisms mediating the inhibitory influence on infant responses are reviewed.

关 键 词：母源性抗体 病毒性疾病 病毒感染 

分 类 号：R392[医药卫生—免疫学]