海藻酸钙/壳聚糖磁性微胶囊的制备及研究  

Preparations and Research of CalciumAlginate/chitosan Magnetic Microcapsules

作　　者：赵趁[1] 李莉[1] 陈爱政[1,2] 王士斌[1,2] 刘源岗[1,2] 

机构地区：[1]华侨大学化工学院,福建厦门361021 [2]华侨大学制药工程研究所,福建厦门361021

出　　处：《生物医学工程研究》2011年第2期86-90,共5页Journal Of Biomedical Engineering Research

基　　金：高等学校博士学科点专项科研基金资助课题(20103501120002);福建省自然科学基金资助项目(2010J05027);闽港人才合作项目(MG200905);华侨大学高层次人才科研启动项目(09BS504)

摘　　要：采用高压静电法制备磁性海藻酸钙/壳聚糖微胶囊,Minitab全因子实验考察不同制备条件对微胶囊形貌、粒径分布及破损率的影响。以超氧化物歧化酶(SOD)为模型药物,考察磁性微胶囊的包封率、载药量及体外释放性能,并初步研究磁性微胶囊的靶向性。The calcium alginate/chitosan magnetic microcapsules were prepared in a high-voltage electrostatic field.Minitabfactorial experiment was designed to investigate relative significance of the processing parameters on the surface morphology,particlesize distributions and breakage of microcapsules.Using SOD as a model drug,the influence of properties on encapsulation efficiency,drug loading and drug release in vitro were investigated,and the in vitro target properties of magnetic microcapsules were also studied.

关 键 词：磁性微胶囊 高压静电法 壳聚糖 包封率 载药量 靶向性 

分 类 号：R318[医药卫生—生物医学工程] TQ460[医药卫生—基础医学]