Formation of domain structure of erythrocyte membrane in Wistar rat fed with CeCl_3per os  

作　　者：CHENG Yi, LIU Maozi, LI You, LI Rongchang, BAI Chunli & WANG Kui National Research Laboratories of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083, China Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Correspondence should be addressed to Wang Kui 

出　　处：《Chinese Science Bulletin》2000年第5期426-429,共4页

摘　　要：To explore the possibility of absorption of lanthanides via digestive duct and their effects on one membrane structure and permeability of erythrocytes, the fine structure of erythrocyte membrane from Wistar rats, fed for 70 days of daily administration per os with 20 mg CeCl3/kg weight, was imaged by means of atomic force microscopy and FT-IR deconvolution spectra. The results show that, although the erythrocytes maintain the intact shape, the change OT secondary structure, aggregation and crosslinking of the protein particles of membrane surface and the enlarged lipid regions lead to the domain structure formation. This structure might be responsible for the increasing permeability of erythrocyte membrane.To explore the possibility of absorption of lanthanides via digestive duct and their effects on one membrane structure and permeability of erythrocytes, the fine structure of erythrocyte membrane from Wistar rats, fed for 70 days of daily administration per os with 20 mg CeCl3/kg weight, was imaged by means of atomic force microscopy and FT-IR deconvolution spectra. The results show that, although the erythrocytes maintain the intact shape, the change OT secondary structure, aggregation and crosslinking of the protein particles of membrane surface and the enlarged lipid regions lead to the domain structure formation. This structure might be responsible for the increasing permeability of erythrocyte membrane.

关 键 词：AFM FT-IR CeCl₃ domain structure WISTAR rat erythrocyte. 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]