The mechanism of asymmetric reduction catalyzed by a C_2 symmetric bis-amino alcohol catalyst——In situ NMR study of the structure of new type of dual-centered catalyst  

作　　者：赵金铠 韩秀文 刘秀梅 包信和 杭剑峰 姜标 

机构地区：[1]State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China [2]Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Science China Chemistry》2000年第1期40-50,共11页中国科学（化学英文版）

摘　　要：By means of 1H, 13C, 11B NMR, polar transfer DEPT135, DEPT90 and 2D NMR experiments, IR, etc, the structure of the diaminodihydroxyl ligand and its derivatives used in the asymmetric reduction of prochiral ketones were detected. The catalysts derived from the ligand and bo-rane formed in situ were also studied and the structure transformations in solution were monitored.The structure of the catalyst was proved to be a new type of dual-centered catalyst——bis-oxazaborolidine.By means of 1H, 13C, 11B NMR, polar transfer DEPT135, DEPT90 and 2D NMR experiments, IR, etc, the structure of the diaminodihydroxyl ligand and its derivatives used in the asymmetric reduction of prochiral ketones were detected. The catalysts derived from the ligand and bo-rane formed in situ were also studied and the structure transformations in solution were monitored. The structure of the catalyst was proved to be a new type of dual-centered catalyst——bis- oxazaborolidine.

关 键 词：2D gradient experiment in SITU NMR diaminodihydroxylborane bis-oxazaborolidine. 

分 类 号：O643.3[理学—物理化学]