Estradiol potentiates antiarrhythmic and antioxidative effects of intermittent hypoxic rat heart  

雌二醇加强大鼠心脏间歇性低氧抗心律失常及抗氧化作用(英文)

作　　者：张翼[1] 钟宁[1] 周兆年 

机构地区：[1]中国科学院上海生理研究所,上海中国200031

出　　处：《Acta Pharmacologica Sinica》2000年第7期35-38,共4页中国药理学报（英文版）

基　　金：Project supported by the National Natural Science Foundation of China, № 3950052.

摘　　要：To study the effects of estradiol (Est) on antiar-rhythmic and antioxidative effects of intermittent hypoxia in rat heart. METHODS; Ligating and loosening the coronary artery of rat to induce ischemic and reperfusion arrhythmias, using arrhythmia score (AS) to evaluate the arrhythmias, measuring the activity of superoxide dismu-tase (SOD) and the content of malondialdehyde (MDA) in myocardium. RESULTS: AS of arrhythmia induced by ischemia and reperfusion in intermittent hypoxia 28-d group (IH28) and in intermittent hypoxia with Est group (IH14-Est) are lower than that in control group (CON), respectively. AS of ischemic arrhythmia but not reperfusion arrhythmia in Est treated group (ESTG) was lower than that in CON. No significant difference in AS of ischemia and reperfusion existed among CON, vehicle group (VEH), and intermittent hypoxia 14-d group (IH14). The activity of SOD was higher and the content of MDA was lower in IH28 and in EH14-Est compared with that in CON. No significant difference of the activity of SOD and the content of MDA existed among CON, VEH, IH14, and ESTG. CONCLUSION: Est potentiated the antiarrhythmic and antioxidative effects of intermittent hypoxia on rat heart.目的:观察雌二醇对大鼠心脏间歇性低氧抗心律失常及抗氧化作用的影响。方法:结扎和放松冠脉造成心脏缺血及再灌注,以诱发心律失常;并测定心室肌超氧化物岐化酶(SOD)活性和丙二醛(MDA)含量。结果:与对照组相比较,间歇性低氧28天组和间歇性低氧14天加雌二醇组在缺血期和再灌注期,心律失常评分(AS)都显著降低。单纯雌二醇处理组的缺血期AS明显降低,而再灌注期AS无变化。间歇性低氧14天组、溶剂组的AS无显著变化。间歇性低氧28天组和间歇性低氧14天加雌二醇组的SOD活性明显升高,MDA含量明显下降。在间歇性低氧14天组、溶剂组和单纯雌二醇处理组,SOD活性和MDA含量与对照组相比较无明显差异。结论:雌二醇可加强间歇性低氧大鼠抗缺血、再灌注心律失常及心肌的抗氧化作用。

关 键 词：ESTRADIOL intermittent hypoxia super-oxide dismutase MALONDIALDEHYDE ARRHYTHMIA myocar-dial reperfusion injury 

分 类 号：R96[医药卫生—药理学]