Antidiabetic effect of Oenanthe javanica flavone  

水芹黄酮的抗糖尿病作用(英文)

作　　者：杨新波[1] 黄正明[1] 曹文斌[1] 郑鸣 陈鸿艳[1] 张静珍 

机构地区：[1]北京军医学院药理室

出　　处：《Acta Pharmacologica Sinica》2000年第3期49-52,共4页中国药理学报（英文版）

摘　　要：AIM: To study the antidiabetic effect of Oenanthe ja-vanica flavone ( OjF). METHODS: Mice were injected iv with alloxan 90 mg·kg-1 to induce diabetes. Blood glucose, serum lipid, and pancreatic amylase were determined with Automatic Biochemistry Analyser. Serum insulin was determined by radioimmunoassay. The pancreas and islets were examined under microscope. RESULTS: OjF 200 mg·kg-1 reduced the blood glucose in normal mice from 0.5 to 6 h after a single administration ig. OjF 200 and 400 mg·kg-1 ig daily for 10 d decreased the blood glucose in alloxan-induced hyper-glycemic mice (P < 0.05, P < 0.01). OjF promoted the release of insulin both in normal and in diabetic mice. OjF decreased serum triglyceride and raised the lowered pancreatic amylases in diabetic mice (P <,0.01, P < 0.01). The islet-injured changes of QjF-treated group were similar to those of control in histology examination, but to a lesser degree. CONCLUSION: OjF possessed the hypoglycemic and hypotriglyceride actions, mainly concerned with promoting release of insulin from B-cells in islets of langerhans .目的:研究水芹黄酮(OjF)的抗糖尿病作用。方法:给小鼠尾静脉注射四氧嘧啶90mg·kg^(-1),造成高血糖动物模型。用自动生化分析仪测定血糖、血脂和胰淀粉酶。放免法测定血清胰岛素。光镜下观察胰腺和胰岛的组织学变化。结果:一次ig OjF 200mg·kg^(-1)后0.5-6h,可使正常动物血糖降低。重复给药10天,OjF 200mg·kg^(-1)和400mg·kg^(-1)均使四氧嘧啶糖尿病动物血糖明显降低(P<0.05,P<0.01)。并促进正常动物及高血糖动物胰岛素释放。OjF还能明显降低血清甘油三酯(P<0.01)及升高糖尿病动物降低的胰淀粉酶水平(P<0.01)。组织学观察OjF治疗组胰岛损伤的变化与对照组相似,但程度较轻。结论:OjF具有降低血糖和甘油三酯作用,并对胰腺损伤有一定的拮抗作用。OjF降血糖作用主要是由于促进了胰岛B细胞释放胰岛素。

关 键 词：Oerumthe javanica flavones bloodglucose insulin experimental diabetes mellitus hypo-glycemic agents lipids and antilipidemic agents amy-lases islets of Langerhans 

分 类 号：R285[医药卫生—中药学]