Chiral guanidine catalyzed Michael addition reaction and Diels-Alder reaction of anthrone and N-methylmaleimide  

作　　者：彭斌 成克军 马大为 

机构地区：[1]Department of Chemistry, Fudan University, Shanghai 200433 , China [2]State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2000年第3期411-413,共3页中国化学（英文版）

基　　金：Project supported by the Chinese Academy of Sciences and the National Natural Science Foundation of China (grant No. 29725205).

摘　　要：Two chiral guanidines were evaluated as catalysts for the reaction of anthrone (1) with N-methylmaleimide (2). When guanidine 5 was used, the Michael adduct 4 was isolated as a major product. The best enantioselectivity (70% ee) was obtained when the reaction was carried out in THF at -20°C.Two chiral guanidines were evaluated as catalysts for the reaction of anthrone (1) with N-methylmaleimide (2). When guanidine 5 was used, the Michael adduct 4 was isolated as a major product. The best enantioselectivity (70% ee) was obtained when the reaction was carried out in THF at -20°C.

关 键 词：Chiral catalysts GUANIDINE CYCLOADDITION michael addition 

分 类 号：O643.3[理学—物理化学]