中草药复方的抗氧化与改善皮肤水分的作用研究  

Research of Anti-oxidation and Improving the Water Content in Skin of Compound Chinese Herbal Medicine

作　　者：蒋平[1,2] 肖百全 雷夏凌 张红 郭健敏 杨威 戴忠[1] 

机构地区：[1]广东医学院药理教研室,湛江524000 [2]广州医药工业研究院,广州510240

出　　处：《中国医药导刊》2011年第10期1771-1773,1759,共4页Chinese Journal of Medicinal Guide

基　　金：2006年粤港关键领域重点突破项目"华南创新中药研究开发与技术服务中心(平台)";项目号:2006A35003001

摘　　要：目的:观察由杭白菊、珍珠粉、当归、胶原蛋白组成的中草药复方的抗氧化与保湿作用。方法:采用裸小鼠皮下注射D-半乳糖建立亚急性衰老模型,昆明小鼠建立黄褐斑模型,观察中草药复方的抗氧化与改善皮肤水分的作用。结果:中草药复方(26.4g生药/kg)能改善D-半乳糖衰老模型造成的皮肤水分减少,增加皮肤超氧化歧化酶(SOD)、1型胶原蛋白、羟脯氨酸;减少皮肤中丙二醛(MDA)的生成。中草药复方(26.4g生药/kg)能增加黄褐斑小鼠肝脏的GSH-Px、SOD,减少肝脏脂褐质、MDA、酪氯酸酶;增加皮肤中的GSH-Px、NO;中草药复方各剂量组对皮肤酪氯酸酶、透明质酸及血液流变学各参数无显著影响。结论:由杭白菊、珍珠粉、当归、胶原蛋白组成的中草药复方,具有一定的促进皮肤抗氧化及保湿的作用。Objective： To study the anti-oxidation and moisturizer effect of a compound Chinese herbal medicine,which were composed of flos chrysanthemi, pearl powder, Chinese Angelica and collagen protein.Methods： D-galactose was subcutaneous injected in nude mouse to made subac.senescent animal model, and moth-patch animal model was made by Kunming mice.Then administration follow the project and observed anti-oxidation and moisturizer effect of the compound Chinese herbal medicine.Results： The water content, SOD, collagen protein, hydroxyproline level were improved and MDA level was reduced in the skin of the subac.senescent animal model by the compound Chinese herbal medicine at the dose of 26.4g/kg.Thc GSH-Px, SOD content in the liver were improved, MDA, monophenolase in the liver were reduced, GSH-Px and NO in the skin were improved too by the compound Chinese herbal medicine at the dose of 26.4g/kg.But the compound Chinese herbal medicine have no effect on the monophcnolasc, hyaluronic acid level and hemorheology. Conclusions： The compound Chinese herbal medicine which were composed of flos chrysanthemi, pearl powder, Chinese Angelica, collagen protein have the effect of anti-oxidation and moisturizer.

关 键 词：胶原蛋白 皮肤老化 抗氧化 皮肤含水量 

分 类 号：R285.5[医药卫生—中药学]