紫草素滴丸制备工艺的研究  

Study on Preparation of Shikonin Dropping Pills

作　　者：冀文斌[1] 刘涛[2] 

机构地区：[1]内蒙古医学院附属人民医院,呼和浩特010050 [2]内蒙古医学院,呼和浩特010010

出　　处：《中国医药导刊》2011年第10期1804-1805,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:考察紫草素滴丸的制备工艺,设计正交实验,确定最佳工艺条件。方法:以聚乙二醇4000为基质,二甲基硅油为冷却剂,滴制工艺为:滴制温度85℃,冷却液5～25℃梯度冷却,滴距5cm,滴速40滴/min。结果:该工艺制得的滴丸圆整度好,丸重差异小,崩解时限为21 min,符合药典规定。结论:该工艺适合紫草素滴丸的制备。Objective：To study the technological parameters of the new drug Shikonin Dropping Pills and to establish the best conditions, the preparation conditions were optimized by orthogonal design.Methods：PEG4000 was an optimal base and methyl-silicon oil was an optimal refi＇igerant.The preparation process was as follows： The dropping system temperature was 85℃, the condensale temperature was 5-25℃ by gradient cooling, the dropping distance was 5 cm, and 40 drops/min.Results：The dropping pills made by this technology had good properties of shaping and small weight deviation.The disintegration time was 21 min, which conformed to the standard pharmacopoeia.Conclusions： This method is suitable for the preparation of Shikonin Dropping Pills.

关 键 词：紫草素滴丸 制备 正交实验 

分 类 号：TQ461[化学工程—制药化工]