环磷酰胺冲击疗法与硫唑嘌呤疗法对狼疮性肾炎的疗效比较  

A comparison of therapeutic efficacy of cytoxan pulse therapy versus azathioprinum in lupus nephritis.

作　　者：徐向进[1] 冯修高[1] 陈频[1] 

机构地区：[1]福州总医院,福州350025

出　　处：《南京部队医药》2000年第2期8-10,共3页

摘　　要：目的比较环磷酰胺(Cytoxan,CTX)静脉冲击疗法和口服硫唑嘌呤(Azathioprinum,AZ)疗法对狼疮性肾炎(lupus nephritis,LN)的临床疗效。方法将42例 LN 患者随机分为两组:CTX 冲击治疗组(CTX 静滴,每2周1次,每次8～12mg/kg,连用2天,积累总剂量≤150mg/kg,以后每3个月注射 CTX,连用2天);AZ 组(口服 AZ 1～2.5 mg/kg)。两组均同时口服常规剂量的泼尼松。结果 CTX 冲击治疗组6个月及12个月时的病情缓解率分别为55.4%、89.3%;AZ 组则分别为23.6%、64.3%。CTX 冲击治疗组的疗效显著高于 AZ 组(P<0.01),而且在血尿、尿蛋白、肾功能恢复及血清补体,γ-球蛋白、抗 ds-DNA 及 ANA 转阴的时间等方面显著低于 AZ 组(P<0.01)。结论 CTX 冲击治疗组有利于及时控制 LN 病情,疗效好,且在副反应方面与 AZ 组相比无显著差异,是治疗 LN 的首选方法。Objective Comparing the clinical effect between cytoxan(CTX)pulse treatment(iv-CTX)and azathioprinum(AZ)in the treatment of lupus nephritis.Methods 42 LN cases were divided into two groups.Intravenous CTX pulse treatment group, (once,every 2 weeks,8～12 mg/kg,every day,for two days,total dosages≤150 mg/kg,then CTX for two days every three months),and oral AX treatment group(AZ dosage,1～2.5 mg/kg,1/d).Prednisone were also given to the two groups in routine dosages.Results Remission rate was higher significantly in CTX treatment group than that in AX treatment group in 6 months (55.4%vs 23.6%)and 12 months(89.3%vs 64.3%).There was no significant difference between the 2 groups regarding the severity of side effect andits incidence.Conclusion CTX pulse treatment is an effective method and first selective treatment in con- trolling LN

关 键 词：狼疮性肾炎 环磷酰胺 硫唑嘌吟 

分 类 号：R593.242[医药卫生—内科学]