一种新型光学纯胡椒醛基氮杂环丙基羧酸酯的合成与表征  

Synthesis and characterization of a new optically pure 3,4-methylenedioxyphenyl aziridino carboxylic acid ester

作　　者：赵文献[1,2] 李高伟[1] 张锟[1] 陈东丽[2] 刘念[2] 雷晓明[2] 

机构地区：[1]商丘师范学院化学系商丘师范学院有机新材料合成重点实验室,河南商丘476000 [2]郑州大学化学系,河南郑州450052

出　　处：《商丘师范学院学报》2011年第6期38-40,共3页Journal of Shangqiu Normal University

基　　金：国家自然科学基金(No.20972091)资助项目;河南省科技攻关项目(No.092102210121);商丘师范学院博士科研启动基金支持项目

摘　　要：为发展新型手性配体,降低手性催化剂的合成成本,检验由芳醛与手性氨基酸酯缩合、还原反应的普适性,以L-丝氨酸为手性源,经酯化,缩合,还原氨化,关环等反应,设计合成了一种新的胡椒醛基氮杂环丙基羧酸酯5,其结构通过IR,1H NMR,13C NMR,HRMS进行了表征.发展了一条高效便捷合成这类具有光学活性化合物的方法.For the development of new chiral ligands,reducing the cost of chiral catalysts and examining the universality of condensation and reduction of aromatic aldehydes with chiral amino acid ester,we designed and synthesized a new 3,4-methylenedioxyphenyl aziridino carboxylic acid ester from L-serine through esterification,condensation and reductive amination,which developed a highly efficient and convenient method for synthesis this kind of optically active compounds.The structure of aziridino carboxylic acid ester was confirmed by IR,1H NMR,13C NMR and HRMS.

关 键 词：胡椒醛 L-丝氨酸 氮杂环丙基羧酸酯 不对称合成 

分 类 号：O621.3[理学—有机化学]