结节性甲状腺肿术后抑制治疗时间研究  

Study on suppressive therapy in patients with multinodular goiter after thyroidectomy

作　　者：李燕书[1] 王海刚[1] 张立献[1] 何柳佳[2] 黎辉[1] 马顺茂[1] 赵文增[1] 祁荣[1] 王巨泽[1] 孙晓艳[2] 

机构地区：[1]河北医科大学附属华北石油管理局总医院普外二科,河北任丘062552 [2]渤海石油职业学院护理系,河北任丘062552

出　　处：《中国误诊学杂志》2011年第32期7828-7829,共2页Chinese Journal of Misdiagnostics

摘　　要：目的探讨结节性甲状腺肿患者行甲状腺切除术后抑制治疗的作用起始时间与腺体切除范围的关系。方法将60例结节性甲状腺肿患者行单侧切除组30例和双侧切除组30例,分为抑制治疗组(n=15)和对照组(n=15),于术后第5天、第9天和第14天检测血清促甲状腺激素(血清s-TSH)水平,配对比较手术前后变化。结果单侧切除患者:术后第5天和第9天两组的血清s-TSH无明显差别,而术后第14天,抑制治疗组的血清s-TSH明显降低(P<0.05);双侧切除组患者:术后第5天、第9天和第14天抑制治疗组的血清s-TSH均显著下降。结论术后促甲状腺激素水平变化与腺体切除范围有关,单侧切除患者宜2周后开始抑制治疗,双侧切除患者术后应立即开始抑制治疗。Objective To study the alterations of the serum TSH in patients with multinodular goiter after thyroidectomy,and to assess the relationship between time of suppressive therapy and extent of thyroidectomy.Methods Sixty female patients with multinodular goiter were divided into unilateral resection group（n=30） and bilateral resection group（n=30）.Then each group was divided into suppressive therapy group（n=15） and control group（n=15）.The serum TSH test was done at day 5,day 9 and day 14 after thyroidectomy.The serum TSH levels were compared.Results Comparation between two groups in unilateral resection group：There was no difference at day 5 and day 9 post-operative.But the serum TSH decreased obviously in the suppressive therapy group.Comparation between two groups in bilateral resection group：The serum TSH in control group increased significantly at day 5,day 9and day 14 post-operative.Conclusions There is relationships between the alterations of the serum TSH and extent of thyroidectomy.Patients with unilateral resection shoud start suppressive therapy at day 14 post-operative,But patients with bilateral section shoud start suppressive therapy immediately after operation.

关 键 词：甲状腺肿 结节性/治疗 

分 类 号：R581.3[医药卫生—内分泌]