重组型牛生长激素抗独特型抗体促生长作用机理研究  

A STUDY ON THE MECHANISM OF STIMULATING GROWTH OF LAMBS BY ANTI-IDIOTYPIC ANTIBODIES RAISED AGAINST ANTI-GH ANTIOBODIES

作　　者：高民[1] 刘晓松[1] 郭文华[1] 王凤武[1] 宋爱军[1] 杨玉莹[1] 卢炳奎[1] 卢德勋[1] 

机构地区：[1]内蒙古畜牧科学院,内蒙古呼和浩特010030

出　　处：《动物营养学报》1999年第S1期123-131,共9页CHINESE JOURNAL OF ANIMAL NUTRITION

摘　　要：选用六月龄内蒙古半细毛羯羊8只按体重相近原则分为3组 :(1)对照组、(2)生长激素处理组、(3)抗独特型抗体组。各组动物日粮组成、营养水平及饲养管理相同。研究抗独特型抗体对动物蛋白、糖、脂肪代谢的影响 ,从而确定其促生长作用机理。结果表明 ,这种免疫调节剂发挥了与生长激素类似的促生长、改善胴体品质的效力 ,尽管其效力较弱(特别在提高日增重方面) ,但在氮代谢效率方面二者相当。进一步研究发现这种促生长作用是在组织代谢层次上实现的 ,具体讲就是通过降低尿素再循环、增加糖异生、提高组织氮沉积量途径来达到增加蛋白组织合成目标。Eight Inner Mongolian semi-fine wool wethers aging six months were divided into three groups:control,GH and anti-idiotypic antiobodies group(accoreling to body weight) to study the effect on carbohydrate,fat and protein metabolism by anti-idiotypic antibodies and to clarify the mechanism of stimulating growth.The results showed that the anti-idiotypic antibodies possessed similar effect of GH in stimulating growth,improving carcase quality,particalar in nitrogen metabolism.The effect of stimulating growth anti-idiotypic antibodies mainly contribated to their effect of decreasing urea-N level in blood,increasing glycogenesis,improving nitrogen depostion in tissues.

关 键 词：生长激素 抗独特型抗体 机理 

分 类 号：S823[农业科学—畜牧学]