^(99m)Tc-NOET与^(201)T1心肌显像在冠心病诊断中的对比研究  

Compared Myocardial Imaging with 99m Tc NOET and 201 T1 in Diagnosis of Coronary Heart Disease

作　　者：刘生[1] 林增桃[1] 曾世荃[1] 蒋宁一[1] 梁宏[1] 胡平[1] 

机构地区：[1]中山医科大学,广州510120

出　　处：《中山大学学报（医学科学版）》1999年第S1期61-64,共4页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：中山医科大学孙逸仙纪念医院科研基金

摘　　要：目的： 比较９９ｍＴｃＮＯＥＴ（ＮＯＥＴ：Ｎ乙氧基Ｎ乙基氨荒酸钠）和２０１Ｔ１ 心肌显像在冠心病（ＣＨＤ） 诊断中作用。方法：ＣＨＤ组：２３ 例，其中冠脉造影１４ 例；对照组：８ 例，其中冠脉造影２ 例。所有对象均进行９９ｍＴｃＮＯＥＴ及２０１Ｔ１ 运动—再分布ＳＰＥＣＴ显像。结果：①运动及再分布显像的心肌节段的放射性摄取一致性分别为２６９／２７９（９６．４％ ， Ｋ ＝ ０．８９ ±０．０６） 和２６０／２７９（９３．２％ ，Ｋ＝０．７９±０．１８） ，一致性极好。②在本研究中，９９ｍＴｃＮＯＥＴ心肌显像诊断ＣＨＤ的敏感性和特异性分别为９１．３％ 、８７．５％ ，而２０１Ｔ１ 分别为８６．９％ 、８７．５ ％ 。９９ｍＴｃＮＯＥＴ和２０１Ｔ１ 显像诊断冠脉病变的敏感性和特异性分别为７１．４％ 、８５．０％ 和７５．０％ 、８５．０％ ，两者比较均无显著性差异。③再分布心肌节段一致性达８０％ 。结论：９９ｍＴｃＮＯＥＴ心肌显像在冠心病上的作用与２０１Ｔ１ 相似；两种显像剂在正常心肌内动力学基本相似，但灌注异常的心肌节段有一定差异，机理不详，可能是两者生物行为不同所致。Objective: To compare the role of 99m Tc NOET [NOET: bis(N ethoxy N ethyl dithiocarbamato) Nitrido] and 201 T1 myocardial perfusion imaging in diagnosing coronary heart disease (CHD). Methods: CHD group:23 cases (14 cases underwent cardiac catherization); normal control:8 cases (2 cases underwent cardiac catherization). All subjects underwent exercise and redistribution imaging with 99m Tc NOET and 201 T1. Results: ①The agreement of myocardial segment radioactivity uptake in exercise and redistribution imaging was 269/279(96 4%,K=0 89±0 06) and 260/279(93 2%,K=0 79±0 18),indicating excellent cocordance. ②The sensitivity and specificity of diagnosing CHD with 99m Tc NOET imaging was 91 3% and 87 5%,repectively; 86 9% and 87 5% with 201 T1. The sensitivity and specificity of detecting lesion of coronary artery disease was 71 4%、 85 0% and 75 0%、 85 0% in 99m Tc NOET and 201 T1 ,respectively. There was no significant difference. ③The agreement of redistribution segment was 80%. Conclusion: 99m Tc NOET myocardial perfusion imaging has similar value to that of 201 T1 in CHD, dynamic change of 99m Tc NOET in normal myocardia is similar to that of 201 T1, but there are some differences in abnormal myocardia. The mechanism is unclear, may be caused by their different biological properties.

关 键 词：放射性核素心肌显像 99m锝-NOET/诊断应用 锝化合物/诊断应用 铊放射性同位素/诊断应用 

分 类 号：R817.4[医药卫生—影像医学与核医学]