洛赛克促进溃疡愈合机制的研究  

Thestudy on the mechanism of facilitation of gastric ulcer healing by omeprazole

作　　者：董秀云[1] 森治树 林三仁[1] 

机构地区：[1]北京医科大学第三医院,100083 [2]东京女子医科大学第二病院内科

出　　处：《中华消化杂志》1999年第S1期15-17,共3页Chinese Journal of Digestion

摘　　要：目的　观察奥美拉唑（ 洛赛克）促进溃疡愈合的机制。方法　（１） 采用胃溃疡胃瘘管的大鼠用中和或比色方法测定胃酸，胃蛋白酶，氨基己糖，用放免或荧光法测定血液和胃液内的胃泌素和组织胺。（２） 用氢气廓氢法测量胃粘膜血流量。（３） 在微需氧条件下培养幽门螺杆菌（Ｈｐ）。结果　洛赛克抑制胃酸，胃蛋白酶的分泌。（２） 增加氨基己糖的浓度和胃粘膜血流量。（３） 洛赛克抑制Ｈｐ 的生长。结论　洛赛克促进溃疡愈合的机制是抑制攻击因子，增加保护因素，抑制Ｈｐ。Objective To study the mechanism offacilitation of gastric ulcer healing by Omeprazole. Methods Weadopted the modelofgastric ulcer with gastricfistulain rats.Thelevelofgastric acid,pepsin and hexosamine weredetected by meansofneutralization orcolorimetry.Throughradioimmunoassayandfluo rophotometry assay,to detectplasmaand gastricgastrin and hisamine.GMBFwas measured by hydrogen gas underclearance. microaerophiliccondition, Hp wasculturedin vitro.Results (1) The ulcerindex(4 .1 ±1 . 4m m2)in the Omeprazoletreated group wassignificantlylessthanthatinthecontrolgroup (9 .5±2.1m m2) . (2) H.pylori wasinhibited by Omeprazole(50mg·L-1) .(3) GMBFwasincreased by Omeprazole (30mg· kg- 1)from 27 .2±4ml·min-1 .100g-1to33.5 ±6ml·min- 1 .100g-1(P< 0.05) .(4) Thegastricacid and pepsin were decreased by Omeprazole (4mg·kg-1) respectively from 0 .3 ±0 .01mEq·2h- 1 .to 0 .14 ±0 . 01mEq·2h- 1 .(P< 0.05) andfrom 1 .7±0.3mg·dl- 1to 0.6±0.06mg·dl-1 .( P< 0.05) .(5) The Hex osamine wasincreased by Omeprazole(4mg·kg-1) from 4.1 ±1 .2μg·ml-1 to 11.3 ±3 .2μg·ml-1( P< 0 . 01) .Conclusions The mechanism ofulcer healingimprovement by Omeprazole was thatitinhibited the ag gressivefactorsandincreased the protectivefactors. Moreover,itcaninhibitthe growth of H.pylori.

关 键 词：洛赛克 胃溃疡 保护因子 胃粘膜血流 幽门螺杆菌 

分 类 号：R975[医药卫生—药品]