抗心磷脂抗体与原因不明胎儿宫内生长迟缓的关系  

The relationship between anticardiolipin antibodies and fetal intrauterine growth retardation

作　　者：吴佳捷 曾文洁 陈朝晖 鲁扬 

出　　处：《中南大学学报（医学版）》1999年第1期65-67,共3页Journal of Central South University ：Medical Science

基　　金：湖南省卫生厅科研基金

摘　　要：用酶联免疫吸附法（ＥＬＩＳＡ）检测胎儿宫内生长迟缓（ＩＵＧＲ）孕妇血清抗心磷脂抗体（ＡＣＡ），探讨ＩＵＧＲ与ＡＣＡ的相关性。结果显示：①ＩＵＧＲ组与正常妊娠组比较，ＡＣＡＩｇＭ和ＡＣＡＩｇＡ结合指数显著增高（Ｐ＜０．０５）。②ＩＵＧＲ组ＡＣＡＩｇＭ增高与其Ｃ３及Ｃ４下降呈负相关（ｒ＝－０．４１０８，－０．４０９２，Ｐ＜０．０５）。提示ＡＣＡ的产生参与了ＩＵＧＲ的发病过程。To investigate the relationship between anticardiolipin antibodies(ACA) and fetal intrauterine growth retardation(IUGR), serum ACA was determined in 60 pregnant women by enzyme linked immunosorbent assay(ELISA). Binding index(BI) of ACA IgM or ACA IgG in cases with IUGR( n =30) was significantly higher than that in normal pregnant women( n =30)( P <0.05). There was no obvious relationship between the weight of neonate and BI of ACA IgM( r =0.1904), ACA IgA( r =0.1829) or ACA IgG( r =0.2013) in IUGR group. Increased ACA IgM had a negative association with C 3 ( r =-0.4108, P <0.05) and C 4 ( r =-0.4092, P <0.05), respectively. After routine therapy for IUGR during 27～35 weeks' gestation, the weights of neonates were 2436.87±437.29 gram in ACA IgG positive group( n =15) and 2905.33±195.95 gram in ACA IgG negative group( n =15). There was a statistical significance between these two groups( P <0.01). It is concluded that ACA may play an important role in the pathogenesis of IUGR. The determination of ACA is also useful for early diagnosis and treatment of IUGR.

关 键 词：胎儿生长迟缓 妊娠 抗体.抗心脂 

分 类 号：R714.51[医药卫生—妇产科学]