急性颅脑损伤患者脑脊液中髓鞘碱蛋白的变化及其意义  

The Significance and Change of the Cerebrospinal Fluid Myelin Basic Protein for Acute Craniocerebral Injure

作　　者：徐育林 杨新宇[1,2] 杨树源[1,2] 王明璐[1,2] 

机构地区：[1]桂林市第二人民医院外二科 [2]天津医科大学总医院神经外科

出　　处：《华夏医学》1999年第3期33-34,共2页Acta Medicinae Sinica

摘　　要：目的：为探讨急性颅脑损伤患者脑脊液（ＣＳＦ）中髓鞘碱蛋白（ＭＢＰ）的变化及意义。方法：用放射免疫分析法测定３４例急性颅脑损伤组患者ＣＳＦ中ＭＢＰ。结果：ＣＳＦ中ＭＢＰ在急性颅脑损伤组明显高于对照组（Ｐ＜０．０１），在ＡＤＣＩ患者明显高于ＡＬＣＩ患者（Ｐ＜０．０１）；ＡＤＣＩ患者入院时ＧＣＳ明显低于ＡＬＣＩ患者，而ＧＯＳ明显差于ＡＬＣＩ患者（Ｐ＜０．０１）；ＭＢＰ与ＧＣＳ和ＧＯＳ均呈明显负相关（ｒ＝－０．６１２，ｒ＝－０．５９８，Ｐ＜０．０１）。结论：急性颅脑损伤患者ＣＳＦ中ＭＢＰ升高，测定ＣＳＦ中ＭＢＰ有助于估计急性颅脑损伤患者病情轻重及预后；有助于ＡＤＣＩ的诊断。Objective:To study the change of Cerebrospinal fluid(CSF) Myelin Basic protein(MBP) for acute craniocerebral injure.Methods:MBP of 34 cases acute craniocerebral injure was determined by radioimmunity assay.Results:MBP of acute craniocerebral injure was clearly higher than those of control (P<0.01);MBP of acute diffuse craniocerebral injure (ADCI) was higher than those of acute local craniocerebral injure (ALCI) (P<0.01); Glasgow coma scale (GCS) of ADCI was lower than those of ALCI and GOS of ADCI was lower than those of ALCI (P<0.01);MBP of acute craniocerebral injure was negatively correlated with GCS and GOS (r=-0.612,r=-0.598,P<0.01). Conclusion:MBP of acute craniocerebral injure was higher than those of controls,it plays an important role in estimation and prognosis of acute craniocerebral injure by determining MBP,also in diagnosis of ADCI.

关 键 词：急性颅脑损伤 脑脊液 髓鞘碱蛋白 

分 类 号：R446.14[医药卫生—诊断学]