SLE患者T淋巴细胞亚群和sLL-2R的变化  

Change of T lymphocyte Subsets NK Cells and sIL 2R in SLE Patients

作　　者：许荣 李培成[1,2] 

机构地区：[1]上海市光华医院类风湿实验室 [2]上海中医药大学附属医院

出　　处：《华夏医学》1999年第4期19-20,共2页Acta Medicinae Sinica

摘　　要：观察全身性红斑狼疮（ＳＬＥ）患者的Ｔ淋巴细胞亚群、ＮＫ细胞及可溶性白介素２受体（ｓＩＬ－２Ｒ）的变化以了解患者细胞免疫调节紊乱的机制。采用流式细胞仪对４０例ＳＬＥ患者和３０名正常对照组进行ＣＤ３＋、ＣＤ４＋、ＣＤ８＋、ＮＫ等细胞表面标志检测；采用ＥＬＩＳＡ法检测ｓＩＬ－２Ｒ。结果表明，ＳＬＥ患者血中ＣＤ８＋细胞增加，而ＣＤ４＋细胞和ＮＫ细胞均减少，ＣＤ３＋细胞无明显变化。血浆中ｓＩＬ－２Ｒ明显增高。结论：ＳＬＥ发病与细胞免疫调节紊乱有关。In order to study the immune modulation system in SLE patients,a comparative study of T lymphocyte subsets (CD3 +、CD4 +、CD8 +)、NK cell (using flow cytometry) and sIL 2R (using ELISA method) in forty SLE patients and thirty bealthy controlled subjects was conducted.The results showed that CD8 + lymphocytes were significantly increased in SLE patients,while CD4 + and NK cell were significantly decreased in SLE patients.CD3 + was unaffected.sIL 2R was significantly increased in SLE patients. Conclusion:The risk of SLE patients was correlated to the dysequilibrium of lymphocyte immune modulation.

关 键 词：全身性红斑狼疮 T淋巴细胞亚群 NK细胞 可溶性白介素2受体 

分 类 号：R593.241[医药卫生—内科学]