Radio Active Tracingsin Brains of Fetal Mice Conceilled by Dan Mice after with ^(125)I Labelled Toxoplasm a Gondii  

作　　者：Wang Haiqi(王海琦) Mei Weining(梅尉林) Shao Yanan(邵亚男) Zhang Jianning(张建宁) [WT5,5”BZ]Department of Obstertrics and Gynecology, the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029, P. R. China 

出　　处：《The Journal of Biomedical Research》1999年第2期65-69,共5页生物医学研究杂志（英文版）

摘　　要：I labelled T. gondii parasites were injected via tail vein into 14 day pregnant mouse( Kunming strain). Radioactive tracings of fetal train and pathologic changes were studiet. The results revealed that infection rates in the pregnant mice and in their fetal heads were 30.60% and 71.2% respectively. The ratio of the radioactivity between the fetal heads and the fetal trunks was 1.32-5.95 , being directly proportional to the durations of infection. Autoradiographs of light and electron microscopy indicated that the parasites appeared in the neurogliocytes of the fetal mice as early as 4 8 h post infection, and might be seen in the nucleus 48h after infection with degeneration and rupture of the cells. Numbers of the cranial nerve cells was distinctively reduced at 72h post infection. This study thus provided the experimental pathology evidence for the development of fetal neural malformation and cerebral lesions from T. gondil infected dam mouse.I labelled T. gondii parasites were injected via tail vein into 14 day pregnant mouse( Kunming strain). Radioactive tracings of fetal train and pathologic changes were studiet. The results revealed that infection rates in the pregnant mice and in their fetal heads were 30.60% and 71.2% respectively. The ratio of the radioactivity between the fetal heads and the fetal trunks was 1.32-5.95 , being directly proportional to the durations of infection. Autoradiographs of light and electron microscopy indicated that the parasites appeared in the neurogliocytes of the fetal mice as early as 4 8 h post infection, and might be seen in the nucleus 48h after infection with degeneration and rupture of the cells. Numbers of the cranial nerve cells was distinctively reduced at 72h post infection. This study thus provided the experimental pathology evidence for the development of fetal neural malformation and cerebral lesions from T. gondil infected dam mouse.

关 键 词：I  labelled T. gondii fetal mice redioactive tracing AUTORADIOGRAPHY 

分 类 号：R965[医药卫生—药理学]